Reta and explosive đź’©?

Drew_19

Drew_19

Well-known member
I'm still taking the 2mg dose, and last week I had a terrible bout of watery diarrhoea that gradually got better. It felt a lot like food poisoning, so I'm not sure if it was something I ate or caused by the Reta. Has anyone else had this? Does this sound like a typical side effect? Should I lower the dose or maybe skip a dose?
 
This is a pretty common side effect. If it started after your injection, it's probably the Reta. I'd consider dropping to 1 mg.
 
The effects on how your gut moves things can be a bit unpredictable; it can either block you up or give you the runs. If you stick to a regular dose, you'll hit peak levels around week 4, so the amount in your blood should be highest a day or so after each shot and get slightly higher each week. The https://glp1plotter.com/ site is useful for visualising this, as it's quite different from most drugs because it's absorbed slowly and lasts a week. Side effects go hand-in-hand with peak blood levels. I agree with Clean-Gang on lowering the dose to 1mg for a bit and then increasing it more gradually, like going up to 1.5mg next time. Usually, stomach issues are worst in the first 1-3 months and then get better for most people. Increasing the dose slowly helps minimize this.
 
I've been on Reta for about 4 months, just increased my dose from 3mg every 5 days to 5mg every 5 days, and I've had the poops since. Also changed to a different batch of Reta when I upped the dose. Got a couple of ideas why, but Imodium seems to work. Hopefully it's just a short term thing.
 
It happened to me during my second week of tirzepatide, and then again in my second week of retatrutide. Just once each time, though. I'm gonna try to stick it out for another week and see if it goes away.
 
Soluble fiber might also be useful. And probiotics such as Florastor Advanced.

Diarrhea is what my pharmacist warned me about the most, saying it's a common reason people quit taking tirz completely. For many on GLPs, it can be the worst they've ever experienced, especially if they had IBS-D to begin with.
 
It's not that uncommon, since week 4 after your first injection is when the Reta levels start to peak and level off. So, expect a bit more trouble this week and next.

Here are some things you could do:
  • Go back to 1 mg or 1.5 mg and stay there for a month. As your body adjusts, slowly increase it to 2 mg. You might need to increase the dose more slowly to give your body time to adapt.
  • Keep going and deal with it and hope your digestive system gets used to it sooner rather than later (not my favorite option).
  • Keep track of what foods might be causing the problem. When I started, fatty or oily foods did it. You might be able to stay at 2 mg if you avoid those foods.
Of course, you might just have food poisoning, but I doubt it.
 
LeanWine said:
I had the opposite problem recently. I was totally bunged up because of these meds. I took something to get things moving, and BAM, firehose! I'll never do that again! Be careful, people!
Click to expand...

Yeah, stimulant laxatives like senna can make your colon lazy if you use them a lot. They basically force your gut to move, which can backfire over time. Gentler options like magnesium might be better.
 
My go-to for constipation is sugar-free candy with sorbitol! Just gotta be careful not to eat too much, because... you know.
 
I had a similar experience when I started sema. Everything just stopped for days! Lettuce seemed to help, but it was rough.
 
It's worth remembering that GLP-1 meds can sometimes cause more serious problems, like pancreatitis. I recently heard of someone landing in the hospital because of it, even after being on Ozempic for a couple of years. It's rare, but something to be aware of.
 
Watch if it's reconstituted by IU or grams — dosing's different. Bac water rule: 1ml per 10mg unless it's over 30 — then split to 0.5ml per 10mg for concentration. Most vials are 3ml. 0.1ml = 0.5mg.
 
Got a close friend, basically a sister, that I told about everything. She kept asking how I lost the weight and I didn't want to lie—she had a failed surgery and was really struggling. I explained the risks and side effects clearly. She was scared like she should be. But seeing my results, she wanted to try. I just asked for full bloodwork. She understood and made her choice. Happy now and no regrets.
 
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