Reta Dosage & Weight Loss - What to Expect?

Sounds like you're responding well! Most folks shed around 1 to 1.5lbs each week at the beginning, when they are on lower doses.
 
Quick update: Actually at 13lbs lost now. Dropped from 164 to 151lbs. My strength feels okay, but I definitely get tired faster - feels like I'm holding onto muscle but my stamina is way down.
 
Oh, also, I recently started taking Ritalin and Wellbutrin for ADHD, so that's probably also cutting my appetite and adding to the weight loss.
 
That's an interesting point about Ritalin. I never considered it for weight loss. Maybe it improves focus, or it could have a combined effect with the Reta?

I'm using Tirz and it works great. I dumped 6lbs the first week, then around 3lbs a week for the next month and a half. It has slowed down now, but I am still losing 1 to 1.5lbs a week. I don't want to up my dose (currently 7.5mg), but I might have to. I'm down nearly 40lbs in about 2 1/2 months.

I'm really working hard. I'm very careful with my diet, track all my calories, and spend an hour at the gym 6 days a week. Every night I fight the urge to hit the fridge! I think the Tirz gives me that tiny extra bit of determination, or maybe it helps focus my ADHD tendencies and all my efforts into one outcome?

For background, my doc put me on Ozempic a couple years back, and I actually gained weight. And since my insurance doesn't cover weight loss meds it was expensive, so I quit after a month. No synergy with that stuff!
 
I'm using Mounjaro (Tirz) and have lost 25kg/55lbs since Oct 2025, still got 20kg more to lose till I'm at my goal 85kg/187lbs
 
I've lost 25lbs. Started reta on Feb 2nd at 2mg. I learned a painful lesson about serving sizes and how slowly food empties from my stomach 2 days later. I dropped to 1.2mg over the next 3 weeks and went up to 1.6mg. I just upped it a full mg this week to 2.5mg.
 
I started at 2mg for a month, then bumped up to 4mg for another month, so after 2 months I'm down around 22lbs, which is about 2.75lbs/week. Gonna do one more 4mg shot tomorrow morning then move to 5mg. That'll leave me with 2 doses of 5mg on hand.

That seems like a lot to lose in a month, but what do I know?
 
I agree with MorningYoga_22, that initial loss is unusual. That tough lesson I learned 2 days after starting gave me almost a 10lb head start that I didn't want. But I'm not complaining. Still, I'm losing about 3lbs/week. I monitor my muscle mass each time I weigh in, and apart from some early muscle loss that first week, I'm holding pretty steady.
 
Can you share more specifics about this 'hard lesson'? I just did my first 1mg dose, and I'm used to fasting with big meals between fasts for weight loss (also drinking my electrolyte water and taking vitamins/supps). Is this a bad approach on reta?
 
Not realizing how quickly peptides begin to work, I ate a huge dinner and 2.5 oranges the next evening after my first dose. I was also taking omeprazole, which slows digestion. Plus, I had a seltzer late that afternoon. All that together and I had diarrhea for 3 days straight. Like colonoscopy prep. I was so sick, I could barely keep down broth. It took almost 3 days to eat solid food again. But that's just me. I ate the oranges because I felt constipated, and usually 1 1/2 oranges does the job. It'll be a while before I eat oranges again.
 
Started on the 17th with 1mg Tirz (wanted to start low), then 1.67, then moved to Reta Sat at .5 (low again to be safe). Eating well, but only lost 3lbs (I know it's a low dose). Going up to 1mg Reta next. Need to drop 50lbs, so I have to move up!
 
It's kind of scary to think about. They just released a study where they looked at what happened after people stopped GLP-1 meds after reaching their target weight, and the average weight gain after a year was 65-70% of what they had lost. Are we talking about pinning this stuff forever?
 
I'm inspired by these results! I saw someone post about their progress: SW: 203, CW: 170, GW: 130. I'm hoping to see similar progress!
 
Salad_Strong said:
I'm inspired by these results! I saw someone post about their progress: SW: 203, CW: 170, GW: 130. I'm hoping to see similar progress!
Click to expand...

Wow, that is really motivating. I'm starting to feel more hopeful about this whole process.
 
Someone else posted that they were somewhere around 210/215 lbs in their before pic and really struggling. Said they started feeling better in 2025! That timeline is so encouraging to think about.
 
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