6'1, 307lbs, age 51. I've done 7 weeks at 1mg. I began at 328, so 21 lbs are gone, and my waist shrank 3.5 inches, which tells me belly fat is melting quickly. By a body composition estimate, roughly 15lb of the loss was fat and 5lb lean, and judging by the waist 4.5-6lbs of it was visceral. Overall about 2.8lbs weekly. No appetite problems or bad symptoms, and I'm still dropping, so raising it now would be pointless. Should hunger turn into a problem, or I stall for a few weeks, or visceral loss slows down, then I'll step up. Reta is really a boutique treatment and should be tailored to each person. Dont just follow internet dosing, which is mostly guesswork, or clinical trials, which push hard on speed to finish.