Reta for Type 1 Diabetics?

FartingtonSmythe

FartingtonSmythe

Member
Anyone know if Retatrutide has been researched for Type 1 diabetes? I've heard it's milder than sema, but can't find anything about T1D. Since it affects both Insulin and Glucagon, could it be harmful for someone with T1D? Or am I stuck with semaglutide for a safer, research-backed option?
 
I'd be super careful using anything with a GLP-1 agonist if you have type 1. Maybe look at other peptides that don't mess with those receptors?
 
Why not use them with T1D, though? What makes them unsuitable? I haven't really looked at non-GLP-1s. What are you thinking of specifically? I'm not an expert on these peptides.
 
My understanding is they try to minimize your own insulin. People with type 1 absolutely need to inject insulin. Kinda like how type 1s usually can't take metformin either. Maybe look into AOD, or CJC-1295 with Ipamorelin, tesamorelin, or even MOT-C.
 
Actually, people with Type 1 can and do take Metformin, alongside their injected insulin. I wonder if the mechanism that reduces the body's natural insulin production would even affect an external insulin source?
 
Yep, I'm a T1D and have been on Tirzepatide for a couple of months. I also use a DIY Loop (smartphone app controlling my insulin pump) which handles most of the work.
 
Thanks for the abstracts. I'm trying to figure out how Retatrutide triggers the Glucagon-Receptor and how strongly. Gluconeogenesis in the liver uses fat when glycogen is low, which is interesting.

I'm comparing this to being a T1D after drinking. My glucose drops 16-18 hours after my first drink because my liver finishes processing the alcohol and refills glycogen. A healthy person's beta cells reduce insulin secretion. As a T1D, I can't do that quickly. I use a fast-acting insulin that starts in 20 minutes but lasts 4-6+ hours, based on insulin sensitivity and cortisol. I hope that makes sense!
 
I'm a type 1 and use Retatrutide. It's great! It really lowers my insulin needs and keeps my glucose where I want it. You have to be careful with lows, especially at first. It can work *too* well!
 
I have type 2, but my doc prescribes me reta as long as I keep appointments and we go slow. No issues yet, but I'm not sure how it affects T1D.
 
I started using Mounjaro about a year ago and it's been life changing. I've been dealing with T2 for years. I lift weights 4 times a week now. I've gone from around 270 lbs down to like 175 lbs. All my vitals are looking awesome.
 
A1C_Survivor said:
I started using Mounjaro about a year ago and it's been life changing. I've been dealing with T2 for years. I lift weights 4 times a week now. I've gone from around 270 lbs down to like 175 lbs. All my vitals are looking awesome.
Click to expand...

Dude, losing almost 100 lbs is insane! Amazing work! Did you have to get new clothes?
 
That's amazing progress, A1C_Survivor! I've been on Ozempic for T2, and my A1C is way better. I've lost about 40 pounds. I feel so much better physically and mentally.
 
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