Reta: How bad could it REALLY be?

From what I've read, you've gotta watch out for stuff like pancreatitis, maybe thyroid issues down the road (they saw it in animals), and some nasty stomach problems that could dehydrate you. Gallbladder probs are also a possibility, and low blood sugar if you're already on diabetes meds. Since it is so new, the long term effects are unknown.
 
From what I can tell, they've expanded the trials and made them longer. If they saw something REALLY bad, they wouldn't be doing that. It seems the side effects are probably not much different than tirzepatide. These trials cost a fortune.

I think they extended the trials because the weight loss kept going past the original timeframe. And they want to beat Novo Nordisk. They want reta to be the top weight loss drug for a long time. Even with new stuff coming out, they'll have the most data. I'm fine taking it, as long as it's tested by a third party.
 
We joke so we don't cry. We all know there's some risk, even with prescribed meds. There's always a catch, we just don't know what it'll be yet.
 
Retatrutide might help you drop fat quickly but at what cost?

www.diabetes.co.uk

One person said: "I go to my visits and they’re like, make sure you eat as much as you can. It’s odd to be in an obesity trial and try not to lose any more weight.”

Experts warn about the dangers of rapid weight loss. Side effects can include pancreatitis, gallstones, muscle loss, and weaker bones. Dr. John Batsis said some of his patients on similar treatments became frail and even broke bones.
 
Who knows, maybe all GLP-1s will kill us in 38 years. There's a lot we don't know about drugs that haven't been around for a full lifetime.

But they'd stop the phase 3 trials if they saw major problems. They're extending them to get better weight loss numbers for advertising.

Most risks seem similar to other GLP-1s, with some extra concern about heart rate.
 
The thyroid cancer thing is just theoretical from mouse studies. It hasn't been seen in humans. They just put the disclaimer to get approved faster. Studies actually show lower cancer rates in GLP-1 users.

Plus, they just published mice data in March showing sema has some anticancer effects. Reta had even better effects in mice. We'll see if it holds true for humans, but if it does, reta might be used in cancer treatment.
 
I prefer to think that if it's not a free lunch with these GLP-1 meds, at least it's a free dessert. I just started sema, but given how close I was to being gone at my previous weight, the results feel like a miracle. My situation seems to be genetic. Maybe my "disease" was helpful for surviving in the past, but it's not anymore. I'm hoping I've finally found what my body needs. So, it's not free, and there are side effects, but we're usually better off. While we're alive, it doesn't have to be a total loss.

Sorry if I got off-topic.
 
I totally agree. Lots of meds have side effects, but they're worth it. I'm just saying GLP-1s are so new and positive that it's hard to believe there won't be some unknown side effects eventually. Maybe they're miracle drugs, but I'm still waiting for the bad news.
 
Another point is that even a "perfect" drug can have downsides.

The act of injecting has some dangers, and so does reduced nutrition.

Besides those issues, you might develop an addiction that has you getting questionable stuff from overseas and injecting with little knowledge of the risks.

Like SCUBA diving or motorcycles, these hobbies may be dangerous.
 
Agreed. I'm also taking reta. But I won't say it can't cause death because the trials aren't finished. I can't give a less bad worst case scenario.
 
I also have heart issues (41% EF), so I'm holding off on reta until the studies are done. I don't know if they're including people with heart problems to see if it's safe.

Usually, I say GLP-1s are probably safe because liraglutide and exenatide have been around for about 15 years and had years of studies. Semaglutide and tirz are approved for heart disease, preventing strokes and heart attacks. Will reta be different and cause heart attacks?
 
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