Two and a half mg of Tirz plus 2mg Reta was my setup for a long while, and then I got intense sugar cravings, more hunger and less fullness. So I raised Reta to 4mg through split doses a couple days apart, and moved Tirz to 4mg as well. Both are now 4 weekly. My resting heart rate climbed from the mid 60s to about 78, and sleep is TOUGH. Otherwise no sides and I feel better, but five to six hours nightly won't cut it. I'm hoping my body adapts soon.