Reta messing with your sleep?

Goals

Goals

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Hey, I wanted to start a thread about how reta is affecting people's sleep, anxiety levels, resting heart rate, cortisol, all that stuff.

I've been having trouble sleeping consistently. I wake up way too early and can't get back to sleep, even when I feel exhausted. I'm actually thinking of switching to sema, or maybe combining sema and reta, because I just can't function without decent sleep.

Has anyone else had similar experiences? Did you have the same issues with other GLP-1s? Any experiences you can share would be super helpful!
Thanks!

the reta and extended fasting thread has notes on sleep and meal timing
 
I went through that with both tirzepatide and reta. I'm still on a GLP-1, but I take meds now to help me sleep. I didn't have these problems at the beginning, only when I got to the higher doses. It might not be a direct side effect of the medication, but a result of the metabolic changes it causes. Found this online:

How Metabolic Changes May Influence Sleep

Tirzepatide isn't a sleep aid, but the metabolic effects definitely can impact sleep, sometimes in positive ways, and other times causing minor issues.

* Stable Blood Sugar: Consistent glucose levels during the night can prevent low blood sugar, which can wake you up. By stabilizing your blood sugar, tirzepatide can indirectly lead to better sleep.
* Less Inflammation: Excess fat can cause inflammation that disrupts sleep. As you lose fat, inflammation decreases, which can help your body's natural sleep cycle.
* Sleep Apnea Improvement: Many overweight people have sleep apnea, where breathing stops and starts during the night. Losing weight with tirzepatide can reduce sleep apnea, leading to less snoring and improved oxygen levels.
* Hormone Changes: Weight loss affects hormones like leptin and ghrelin, which control hunger and fullness. These changes can temporarily disrupt sleep, leading to insomnia or vivid dreams. Usually, things stabilize over time.
* Digestive Changes: Tirzepatide can slow down digestion, causing nausea or bloating, especially when you first start or increase your dose. Taking your dose earlier in the day or eating lighter dinners can help.
 
I'm glad someone brought this up, because I've been wanting to post about my sleep changes too. I'm on week 4 of Reta at 3mg. I used to get a solid 7 hours of sleep. Now, I fall asleep fast and sleep great for the first 4 hours, but then I wake up and can't get back to sleep. It's slowly improved to about 5 hours total. At first, I thought it was insomnia kicking in. But now I'm wondering if I just don't need as much sleep anymore. I don't feel tired when I wake up after 5 hours, and I'm fine all day. If I try to sleep longer, I just toss and turn. Maybe 5 hours is all I need now? I'm curious if anyone else has had a similar experience.
 
I've also noticed my sleep is worse since I started Reta. My resting heart rate used to be in the 50s, but now it's in the mid-60s. And my sleep is much more restless. It's the biggest downside for me. I think I'll try cycling it, maybe 12 weeks on and 8 weeks off, and see how that goes. But overall, the benefits are still worth it.
 
I'm taking 15mg of Tirz split into two doses twice a week. To help with sleep and burn visceral fat, I've been on a Tesa/IPA combo for the last couple months. I recently added DSIP, and it's helped me stay asleep longer and get more deep sleep.
 
Ugh, missing sleep is the worst! For me, it only happened when I first started Reta. My RHR went up too, but it's mostly back to normal now. I've been on Reta for about 3.5 months. I actually feel less anxious, not more. What helped was eating some protein and complex carbs about an hour before bed, to counter the cortisol release at night. I also split my dose, but I'm not sure if that really made a difference. Otherwise, it just went away over time. I hope you get some good sleep soon!
 
I went from 15mg tirz, to 2mg reta and 10mg tirz. I also use a CPAP machine, even though I probably don't need it anymore. It's a total game-changer for me. I've had it for years.
 
I wasn't fully stopping breathing, but I got a CPAP too (long story). I can't nap without it, I love a good weekend nap. I'm not giving it up if I can help it.

Perimenopause still wakes me up sometimes with those 3am blood sugar drops and the cortisol rush that comes with it.

I wouldn't be surprised if GLP-1s cause similar problems. Reactive hypoglycemia seems to be part of using them, for me at least.
 
I've noticed that when I don't eat enough calories, I get restless legs. It's hard to describe the feeling, but it definitely keeps me awake. It's not really a Reta thing, because I used to get them when I was cutting calories before I even started GLP-1s.
 
I've been on Reta for a while now and haven't had any sleep issues. But when I got my mum to start it a few months ago, she started complaining about bad restless legs and having trouble sleeping. I suggested a peptide or two to help, but she's not comfortable with those, so I gave her some magnesium spray for her legs, and it's been helping a bit. As for me, the biggest change has been super vivid dreams, which I never had before.
 
I've struggled with insomnia for years and have seen a bunch of specialists. I've tried everything, even sleep therapy. My sleep had been pretty good for a few years, but then I started tirzepatide. It totally messed it up. I couldn't fall asleep and would often be up until 5 AM. Which is a problem when you need to be at work by 8 AM. I ended up going back to my psychiatrist for sleep meds. My main issue is falling asleep, so we found a medication that helps with that. Honestly, I'm sleeping better now than I have in a long time. Hope that helps.
 
Hey Jess1977, I feel you on the insomnia. I read about a guy who had insomnia after stopping TRT, and his doctor suggested Gonadorelin. But some people were saying it's not effective. Maybe something to look into? He also mentioned that glutamine before bed helped some people.
 
It's interesting how GLP-1s can affect sleep so differently for everyone. I saw someone on Reddit mention that their insomnia actually went away after starting Ozempic because it helped regulate their blood sugar. Maybe that's something to consider, Goals? Blood sugar swings can definitely mess with your sleep.
 
i'm between two countries — when i can, i'm looking at peptides for sleep and cognitive stuff. made it through customs with one order using a german package shop, now working on my second shipment.
 
Same thing here. Worst of it was about two days but took a good month to feel normal. Eating more under those conditions makes sense. Pretty sure once the scale moves at a week in it'll feel reinforcing. Fatigue going from brutal to annoying helps you see the upswing.
 
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