Reta sting - why?

[ThinBeer837]

I've sourced Reta from a couple of different places, both look good and get good reviews. How come one of them burns when I inject it, but the other doesn't? I'm down about 35lbs since August, so it's doing its thing, but one feels totally different when injecting. I use the same bac water for both, so I know that's not it. Any ideas?

 

[Jules2006]

Are you filtering it for particles? Maybe the pH is off? Or are you injecting a large amount? I've never experienced a sting, even using different sources.

Edit: I just read that some people have reported this in phase 1 and 2.

 

[ThinBeer837]

No, I just mix the vials with the bac water as instructed. I used the same bottle of bac water. One vial stung when injected and the other didn't. They both look clear once mixed and otherwise look the same. Just from two different places.

 

[Jules2006]

Maybe it's the pH then?

 

[Bold_IMO665]

I've heard that one source is known for having a sting, but supposedly they've taken care of that with more recent batches.

I wish we knew for sure why it happens.

My first Reta was from a local seller of pre-filled pens, and it stung then, so I've always wondered if they were buying from that source.

 

[Dana21]

Interesting. I've used different sources and never had any stinging. Now, GHK-Cu...

 

[Nikki_92]

Just did my first dose of Reta from my usual source, no sting, no problems, just less hunger and continued loss!

 

[MounjaroMission]

For those of you just starting out, I've found that injecting on Thursday mornings helps cut those weekend cravings!

 

[ThinBeer837]

For those of you just starting out, I've found that injecting on Thursday mornings helps cut those weekend cravings!

That's a good tip, thanks! I've been doing mine on Sundays. Maybe I'll try switching it up.

 

[Nikki_92]

Regarding refrigeration, the medication can be left out after the first use for a certain period, but refrigeration promotes stability. I advise my patients to keep it refrigerated to minimize any potential degradation.

 

[Bold_IMO665]

I always keep mine in the fridge. I take it out an hour or so before injecting so it's not so cold! I hate injecting cold stuff.

 

[Avery08]

pH variance between batches is the usual cause - the acidic one stings. Sodium bicarb to adjust, test strip to confirm.

 

[ShrinkingViolet]

NAD Pal does sting longer, that's accurate. Tesa at night is a standard approach. Source difference on sting usually comes down to pH.

 

[Jules89]

Body adapts to the sting faster than expected. The first month is usually the hardest part of it.

 

[Uri_1994]

Concentration and injection speed cause the sting. Room temp and slow push help.

 

[CalorieCounter_44]

The burn difference between two sources is pH and concentration formulation - one is likely more acidic.

 

[The_Sema_Source]

5ml per 500mg gives you the 1mg-per-unit math that makes dosing adjustments clean - it's worth the slightly larger injection volume to avoid both the sting and the calculation overhead.

 

[lab-rat-life]

Sting variance at the same dose is usually the excipient - acetic acid and trace manufacturing contaminants are the common culprits. pH further from physiological neutral increases site irritation even at equal concentrations.

 

[ToneLean]

The reconstitution volume affects the final concentration of the carrier components, including benzyl alcohol, which is the most common sting culprit. At lower dilution the BA concentration per injection is higher and the tissue reaction is more pronounced. Going to a higher water volume reduces that concentration and typically reduces the sting and welt response. Worth testing the higher dilution across a few doses before attributing the reaction to the compound itself.