When I first started, developed an itchy welt post-injection. Switched to a longer needle in the rear and the reaction disappeared completely, never had an issue since. Seems like the fix whenever I get a reaction is just going longer on the needle. Diluting more helps too, always use a generous amount of bacteriostatic water. Skin and hair seem to be looking up lately, but I'm running enough stuff simultaneously that it's hard to credit any one thing specifically. Did notice taking a couple weeks off the blend made my knee pain worse though, so maybe the healing peptides in there are doing the real heavy lifting. Anyway, it's this lovely purple color and I love it, hope it works out for you too!