Reta - When does the magic happen?

Reta hit me pretty hard right from 1mg too - almost uncomfortably strong appetite suppression in the first week. I had to actually remind myself to eat. Everyone responds differently though so not seeing the effect at 1mg doesn't mean it won't come at a higher dose.
 
Starting at 2.5mg and hitting 4mg without much suppression and then cagri switching things up is useful to hear. Reta alone at those doses not doing much is more common than the forums suggest. What did the hunger feel like differently once cagri came into the picture?
 
2mg to 3mg for 4 weeks with no movement and prior Tirz experience in the mix - prior Tirz can sometimes mean the receptor pathway needs longer to show up cleanly on Reta. What's appetite doing, any difference there even if the scale hasn't moved?
 
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