Reta's making me HUNGRY??

[roundtwo-ish]

Did you climb up to 24mg of reta gradually, or all at once? I'm at 10 right now and about to need another bump myself. Long way off from 24 still, but it feels like these meds only really kick in for me once I push toward the ceiling.

 

[almond-maintenance]

One big reason people lifting or into fitness gravitate toward reta over the other GLP1s is that it doesn't eat into muscle the way Tirz and Sema tend to, so not sure where that other info came from. Ran a single 1mg dose weekly for the first month, then split it to twice weekly at 1mg for a couple weeks before pushing to 2mg. Down about 20 pounds in roughly two months, probably faster than a lot of people would recommend, but Reta's genuinely changed how I eat. My diet was terrible going in and I knew it. It's forced better choices - you fill up quicker and stay full longer. People say it's not a miracle drug, and sure, but it's held up solidly even at low doses. A buddy of mine dropped 40 pounds on just 2mg. Only downside on my end lately is trouble falling asleep the past couple nights. Once I'm out though, I sleep straight through from 1-3am until 7.

 

[Turkey]

Wow. Honestly hadn't thought about this at all. Completely lost track of the schedule while pushing hard to switch over to reta. Didn't realize the actual start date on GLP-1s was earlier than assumed, meaning a longer stretch on tirz than thought, which means room for a higher dose than expected.

Also kind of leaning toward 'if it's working, leave it alone.' Appetite's sitting in a really manageable place these days. Eat when hungry, stop when not. Can tell when full but usually finish the plate anyway, no seconds, no sweets though.

Don't want to slash daily calories further since that leaves me sluggish. Not totally convinced cutting out burgers and eating out is the missing piece to hitting a faster weekly rate.

 

[spunky_peeleriii]

Cycled through the full GLP-1 and peptide lineup and ended up settling on retatrutide myself. Eased into it at a lower amount the way most people do, built up gradually, but what really doesn't get discussed enough is how it just... silences things. Not simply 'less hungry' - I actually quit thinking about eating altogether. That nonstop background hum wondering about dinner, checking the pantry, opening the fridge just went completely quiet. Physical changes showed up quickly too, noticeably faster than what sema or tirz ever gave me. A matter of weeks rather than dragging into months. The alcohol piece surprised me the most - I'd typically have a beer or two most evenings, then caught myself realizing I hadn't wanted one in nearly a month. Wasn't even trying to cut back, the urge simply left. The glucagon component feels different in a good way too, more heat, more overall drive. I titrated carefully since past experience with other peptides taught me pushing too fast just invites gut trouble. Patience pays off. At this point nothing else would tempt me to switch.

 

[peanut_dabblerxo]

You'll notice more hunger on higher doses because there's a bigger drop late in the week, and that's completely normal. The top reply here says it well. The aim isn't zero hunger. It's to help you steer your habits off junk choices and onto nutrient dense foods, carbs that come with fiber, plus protein and healthy fats. Meds without new eating habits eventually stall and weight creeps back regardless. I've seen it happen time after time. They're an amazing tool, not a cheat sheet.

 

[apricot_sipper]

I couldnt see your starting weight, and it matters whether youve already lost 50 kilos or 10 and stalled. Rising hunger and slower loss usually mean youve lost a lot already, so the medication has to hold the line rather than only push more loss. If cost isnt an issue, though data is still in its infancy, eloralintide looks like the best add-on: about 11% extra loss in 32 weeks over tirz alone at 15mg. Probably better than cagri for extra loss, as the only cagri trials paired it with sema. Still, adding tirz or cagri is reasonable, or going beyond 12mg of reta, which only really works if side effects at 12mg are minimal, otherwise tirz may be gentler. Start cagri very low, like 0.25mg. Tirz might quiet food noise more effectively than reta does.

 

[lankysourdough45]

Hunger was up for me too in the first couple weeks, right alongside the weight loss and the quiet in my head about food. I went up slow. These days the hunger is way down and I'm not chewing on food thoughts all day, what a relief. I'm running 1.5mg three times a week and sit just a couple kilos off where I want to land, so I'll probably ease off some when I get there. Still get random hunger spikes now and then, usually right when the scale drops. Twice I hit what I figure were dud vials, or maybe bad bac water, and the food gremlins came roaring back and my loss stopped cold until a fresh vial. So maybe how loud the food thoughts get tells you more about whether a vial is working than real hunger does?

 

[DerekwilliamsC]

On your scale my starting appetite sat around minus 100, and Reta brought my hunger to zero. I know what youre thinking: was it genuine Reta or a counterfeit? But this is Reta, the most powerful GLP around, which should blow the fat right off you, so the real question is whether you are simply unlucky.

 

[tirz7-here]

Same here. I asked in a group chat yesterday because I noticed it too. I did start very low since I feared reactions. Suppression was good and food noise dropped a lot, which helps a lot, since eating works as a stimulant for me. Then the planned step to 2mg a week brought the noise right back. Filling up quicker is still there, so it's not all gone. Loss is steady, 800g to 1kg a week, but I can't tell if that's the reta or just eating less.

 

[dozy_traveler66]

real question is why you think youve built a tolerance here. has diet and exercise alone ever worked for you before? remember how the further you got, the harder it got and the hungrier you felt? thats the standard physiological pushback to weight loss, your body defending itself, pushing you toward eating so you dont starve. that response gets messed up for people like us. think about how that appetite spike and crumbling willpower could work against what your glp1 is trying to do. its almost a shame these drugs dont just stop working outright, since a plateau from quitting would make stopping it trivial. everyone here has seen what happens when people come off glp1s, the medication disappears, the hunger doesnt. this is a resistance to losing weight, not the drug losing effectiveness.