62M, former athlete. Prednisone for autoimmune diseases ballooned me to 262lbs during recent years. Started reta 2mg weekly at the end of December 2025. Seventy pounds gone, now 191-192, exactly my goal. Unreal: under 6 months, and the goal is met. Doses rise 1mg a month up to 5mg. Some days I add 1mg of tesamorelin against visceral fat. The reta Im on now is a different make and seems weaker, so I may go to 6mg (3mg twice a week). Stretching the interval lets autoimmune inflammation surge back, so reta holds my weight and my symptoms in check. Hashimotos, mixed connective tissue disease (lupus-like), severe secondary adrenal insufficiency, and myasthenia gravis type neuromuscular issues (highly medication responsive, though labs are negative).