RHR elevated on Reta?

KetoStrong

KetoStrong

Well-known member
I've been on Reta since the fall and dropped about 28 pounds, which is great. My only concern was the higher resting heart rate, especially after my heart incident last summer. I started supplementing with taurine after reading about it, and it's made a huge difference! My RHR went from 83 to 73 bpm in just a day. Just wanted to share that there are solutions if you run into issues with these meds. I highly recommend taurine!
 
That's really good to know. My RHR has crept up since starting GLPs. I just ordered some taurine. What dose are you taking? I got 500 mg capsules and was thinking of starting with 500 every other day and maybe going up to 1500 daily. I'm always a bit careful when starting something new.
 
1000mg seems to be the sweet spot for me. Plus, it gives me a nice little energy boost and a feeling of calm. It's great stuff.
 
I've been taking 1000mg of Taurine for other health reasons, but unfortunately, it hasn't done much for my resting heart rate.
 
I'm also on a beta-blocker, 25mg twice daily. From what I understand, beta-blockers might not directly counter the Reta-induced increase because Reta elevates it through a different mechanism. But it may help lower your baseline RHR.
 
I was prescribed a beta-blocker after my heart incident, but it gave me some undesirable side effects. My doctor switched me to a different one, and I've been okay since then.
 
I take it for lipid management and potential, although not yet fully proven, benefits related to exercise.
 
I keep switching between two different beta-blockers. I was on a low dose of one, but it wasn't enough to control my HR, and increasing it caused my BP to drop too much.

Now I'm on 25mg twice daily of the other, and my BP is a bit higher, and my HR is a bit better.

I really suspect the Tirzepatide was driving it up. My cardiologist agreed when I saw him last week. On 10mg of Tirz, my HR was regularly in the mid-80s while just sitting around. Since I've been decreasing Tirz (currently 5mg) and increasing Reta (currently 2mg, going to 4), my heart rate is in the 70s while sitting. I'll see what happens this week with 4mg. Since I'm almost at my goal, I'm hoping 4-6mg will be my maintenance dose.
 
Thanks for this info, gonna grab some now. My rhr is up like 10bpm since starting. It's in the low 80s now. I heard that after being on Reta for a bit, rhr will go back down. But since you've been on it since November and it hasn't, maybe that's not true.
 
That's only partly true. Reta increases heart rate in two ways:

1. The GLP-1/GIP action stimulates the sympathetic nervous system, which releases norepinephrine at the beta 1 receptors in your heart. Beta blockers directly address this.
2. Reta also affects glucagon receptors in your heart, which increases heart rate through a different mechanism. Beta blockers don't affect this pathway.

The GLP-1/GIP effects of reta on HR are similar to the glucagon effects (based on comparison to Tirz), so a beta blocker will likely counteract a significant portion of the HR increase.
 
Dog_Cake said:
I heard the GI issues with Reta are less than Sema... is this true?
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From what I have read, many people find Reta more tolerable than other GLP-1s and GIPs. Everyone reacts differently, though.
 
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