Scared to start Ozempic!

Groovy_Bro

Active member
Hey, everyone. I'm starting on Ozempic tomorrow, and I'm super nervous. I don't know what to expect. Throwing up is my biggest fear... I can deal with feeling sick as long as I don't actually puke. Any tips to help avoid that? Also, what should I know about food? What to avoid or focus on? Would it be a good idea to talk to my pharmacist before I begin? Thanks for your help!
 
Okay, so here's my usual spiel for people starting out or looking for advice. Hopefully, it's helpful! I add to it when I see recurring questions, so even if you've seen it before, there might be something new!

First, congrats on making this move!

Remember, this is a long game, not a sprint.

Here's some advice I've given countless times, updated with new stuff I've learned:

Don't expect immediate changes. Everyone's body reacts differently. Some see results right away on the lowest dose, others need a higher dose.

The official guidelines say to stay at each dose (.25, .5, 1.0, 1.7, and 2.0 for Ozempic injections; .25, .5, 1.0, 1.7, 2.4 for Wegovy) for at least 4 weeks. I *strongly* suggest increasing by only .25 at a time. You can find click charts online to customize the dose. For example, each .25 increment on a 1.0 pen is 18 clicks.

Stay on each dose for at least 4 weeks. If it's still working well, stay longer. This maximizes effectiveness and minimizes side effects. Increase only when the current dose stops working.

You need to follow the schedule, or you risk side effects. That's why it exists!

When injecting, pinch a good amount of fatty tissue (usually in the belly, but some use the thigh), inject into that area, and hold the needle there for at least 5 seconds after the injection finishes (to make sure all the medication has been dispensed). Also, remove *both* caps from the needle. It barely feels like anything.

I have no experience with the Rybelsuss.

Slow and steady wins the race. I lost an average of 0.1lbs per day. Sometimes I lost a lot, sometimes I plateaued. Some people respond more strongly than others. If you're seeing progress, it's working. 0.5-1lb a week is generally good.

Calculate your BMR and TDEE online to find out how many calories you need to lose weight safely while getting enough nutrition. Eating too *little* won't help. Eat in a safe deficit. Recalculate as your weight decreases. Smaller bodies need fewer calories.

Track your food intake. I like the LoseIt app, but there are many good options. Tracking and staying in a calorie deficit is key.

Prioritize protein and fiber. Protein shakes are great for getting calories and protein in when you don't feel like eating. I like Fairlife and Premier Protein for premades. For powders, get trial sizes to find what you like.

*Drink lots of water!* Ozempic and Wegovy can dehydrate you, and water is essential for weight loss. It helps you feel full longer.

Adding Crystal Lite, Mio, lemon, etc., doesn't make it count less. It all counts. Also, get a water bottle you love.

There are no "bad foods." Fad diets aren't sustainable. Focus on portion control and mindful choices. If you stop eating chocolate, all you'll crave is chocolate.

For "junk food," buy single-size servings. They help with cravings and reduce temptation.

Take body measurements now. The scale might not move, but the measuring tape will.

Take "before" pictures! You might hate them now, but you'll be glad you have them later.

Constipation is the most common side effect; diarrhea is less common. Increase fiber intake. I like All Bran with milk and honey. Restorlax can help for a quick fix. Magnesium supplements can help long-term (if your doctor approves).

For diarrhea, Imodium can help. Avoid oily, greasy, or spicy food. Nausea is another big side effect. Ginger chews, tea, and supplements help. Peppermint tea, protein and fiber before bed, Gravol (Dramamine). If it gets bad, your doctor might prescribe Zofran.

Hair loss is another common side effect due to decreased nutrition and rapid weight loss. Increase protein and add supplements. I increased protein and added biotin and prenatal vitamins. It worked.

Feel free to ask questions! I've been on Ozempic/Wegovy for over 2 years and just hit my goal weight! I'm now weaning down to find a maintenance dose.

Height: 5'4
Age: 35 f
SW:300lbs - October 15/23
CW:150LBS - hit my goal Dec 31/25
GW:150LBS
 
In my case, I felt a bit sick to my stomach at first, maybe for 2-3 days. It got better as the weeks went by. Never threw up or had the runs. I stay away from fried and greasy foods. If you eat too much, you'll feel gross. Listen to your body. Stop when you're full, even if it's a small amount. Drink a ton of water throughout the day. It sounds like a lot, but it's important. I drink coffee in the morning and then start on the water. I use flavored packets sometimes. They count. Focus on protein and veggies. Good luck! I think you'll be happily surprised.
 
I only had a little nausea, never threw up. I had to eat low-fat foods. Pizza or burgers made me feel sick, so stock up on plain protein, fruits, and veggies.
 
I think chatting with your pharmacist would be a great idea; it might calm your nerves. Lots of people don't have bad side effects, so try not to worry too much! Pay attention to your body and how you feel after eating certain foods and amounts. If you get nauseous, ask your doctor for a prescription to help. Drink tons of water – way more than you think you need. Best of luck!!
 
No fried foods, drink lots of tea, and consider some liver support supplements like milk thistle. Stay at the lowest dose possible for as long as you can.
 
Ignore the people saying "Don't eat this... don't eat that." They don't know your body. I eat whatever I want, just less of it.

Listen to your body!

I have zero side effects. Maybe a little nausea now and then, and I can't drink 20 beers anymore. I switched to vodka (oh no!!)...

You'll figure it out and be fine. Millions are on Ozempic; you won't be the one constantly puking.

You can have nausea but not puke? What's that even mean? I'd rather puke and be done with it than feel sick all day. But you probably won't puke.

It's not complicated. People just love to overthink everything online (especially those with negative symptoms).

Just do the shot and forget about it. You'll just eat less.
 
Here's my experience with Ozempic:

First shot - no problems

Second shot - threw up and had diarrhea after 2 hours

Third shot - threw up and had diarrhea all the next day

Weight loss after 4 weeks - around 20 pounds

Fourth shot is tonight. I'm going to eat only noodles and drink so much water I slosh when I walk. That should make the vomiting less unpleasant if it happens again. It's not fun, but worth it because of the results. Don't be scared.
 
Just wanted to add something I forgot. Listen to your doctor! I know it sounds obvious, but some people get advice here and ignore their actual medical professional. That's a REALLY bad idea!
 
The_IMO said:
Stay as long as possible at the lowest dose

This is great advice. I see so many people rushing to increase their dose, and then they end up with terrible side effects. Slow and steady is definitely the way to go with these meds.
 
Ok so I did the shot this morning. Barely felt it, just like some people said. But now I have a headache and feel kind of dizzy. Is that normal this soon?
 
Groovy_Bro said:
Ok so I did the shot this morning. Barely felt it, just like some people said. But now I have a headache and feel kind of dizzy. Is that normal this soon?

Yeah, it can happen. Make sure you're drinking enough. Dehydration can make those side effects worse. Eat something light too. Good luck!
 
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