Sema 7.2mg - worth it?

The study says: "20.7% weight dropped after 72 weeks using the highest dose, compared to 17.5% with the 2.4 mg dose." So, nearly tripling the dose only boosted it 3%. Seems like very little payoff, tbh. What side effects just for that little extra effect? Seems like a marketing push. Cagrisema might come close to matching tirzepatide, but I doubt it'll win. Retatrutide and whoever releases it will probably be top dog. Semaglutide will be 3rd place.
 
Don't forget they have other benefits, too. For JUST weight loss, tirz and reta are probably best. If you need fatty liver support, maybe reta or cagrisema or survodutide. If you have heart issues, maybe skip reta. Sema or cagrisema seem promising for SUD or AUD or BED, plus I think sema helps with brain fog, too.

I think they'll each have a place.
 
Table 1 in that article shows 30-40% in the reta groups with hypertension. What exactly are you considering 'heart issues'? Table 3 lists adverse effects but doesn't mention increased heart rate, so I guess it wasn't too bad. Arrhythmia is very low, it seems.
 
Good point, JerseyGirl_Health. I'm not seeing it specifically mentioned in the article.

It's interesting that some in the placebo group got arrhythmia symptoms. The article mentions people stopping their blood pressure meds, so I am guessing some had high blood pressure and maybe other issues.
 
Maintenance long time, accidentally stocked years worth tirz and sema. Would love magic swallowable pill convenience. Not putting up with all current pill requirements, totally agree.
 
Sema clouded my mom's thinking and she sleeps constantly. Cagri might be worth trying though-different response for everyone. Tesa also gets good reports for breaking past the last 10-15 lb plateau.
 
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