Sema powder stability issues?

[Bee_Quest]

Hi everyone,

I'm really hoping someone can help me figure this out. I've been using freeze-dried Sema in 5mg vials for a while now, mixing it with 0.9% NaCl. It stayed good in the fridge for over a month. But now I've switched to raw semaglutide powder from the same place. I mixed it with NaCl, and I even added 1% benzyl alcohol myself and filtered it with a .22 micron filter to make 5mg in 1 ml vials. I've tried it a few times, but after about two or three weeks, the solution gets cloudy and stringy. Shaking it makes the flakes and strings disappear for a little while, but they come back in like half an hour. Any thoughts on why it's not stable? Could the pH of the filler be off? Should I just use regular 0.9% NaCl? Or maybe some pre-made BAC water? Any help would be greatly appreciated!

 

[Cut_Grind]

It's probably because you're using raw instead of the freeze-dried stuff that worked before. I've never heard of using raw peptides except maybe for skin creams. I'd toss it.

 

[Val_1994]

Why did you decide to go with raw instead of lyophilized? It can't be about saving money. Seems kinda sus.

 

[Cut_Grind]

I saw the original poster asking the same thing all over Reddit, but nobody has a good answer.

 

[BioCrew]

Yeah, twice on Reddit too! And no replies... sounds like a troll to me lol

 

[The_King]

I have the same problem even with freeze-dried sema dissolved in 0.9% NaCl and 1% benzyl alcohol. It starts after about 3 weeks. I'm wondering what's causing it.

 

[Salad_Strong]

I agree with Cut_Grind, stick to what works! Why mess with raw powder when you've had success with freeze-dried? Sounds like a hassle.

 

[BioCrew]

Should I just use regular 0.9% NaCl? Or maybe some pre-made BAC water?

I'd try the BAC water. Never hurts to use sterile water.

 

[The_King]

Has anyone ever had a bad reaction to peptides, like feeling sick?

 

[Val_1994]

I've heard some people say research peptides are okay for people to use. Is that true? I'm a little nervous about trying this stuff.

 

[Bee_Quest]

Thanks for the advice everyone! I was hoping the raw powder would be more cost-effective, but maybe it's just not worth the trouble. I might go back to the freeze-dried vials.