Sema's over for me - crazy side effects!

[rustic_lateadopter36]

Extreme coldness really does stick around. Flannel layers, heated pad, sherpa blanket became my survival kit. The meds work, cold just comes with it.

 

[walnut_wanderer]

I'm locked in for long-term use and honestly I'm okay with it. The $160 monthly cost is worth sacrificing other stuff. Once insurance picks it up, bonus. But even now the life improvement is worth the risk of unknowns. No point spiraling about taking it forever if you've got access and can swing it.

 

[plucky_lowkey4599]

Exactly what I needed to hear. Thank you for sharing your story.

 

[Ant_Story]

The mood change side effect on sema is underreported relative to the GI ones, but it's a recognized pattern - the GLP-1 receptor presence in the brain means some people get appetite suppression and some people get mood dysregulation, and it's not always predictable in advance. Stopping because of psychiatric effects is entirely warranted, and the stomach pain situation is also worth a thorough prescriber review - both together suggest sema's receptor footprint in your system is producing effects beyond the therapeutic target. Tirz uses a different receptor weighting and some people who don't tolerate sema do fine on it.

 

[Jess1977]

2 years for side effects to resolve is the long end - protein and water consistently is the main lever most people find it front-loaded in the first months.

 

[Bio_Loss]

Gallstones from sema is documented but underreported - the rapid weight loss aspect may be the driver more than the drug itself. Slow titration is the right instinct once you're back on something new.

 

[lankyoffduty419]

Been through something very similar. Gallstones that turned into pancreatitis. Spent ten months on Mounjaro.

Agree with the general advice too, getting the gallbladder removed early can help avoid pancreatitis, easily the worst pain experienced personally. Keep monitoring it closely, wishing the best going forward.

 

[Scraps168]

Oh yeah, this stuff hits hard and fast. On it, I never thought about food, never wanted any. But semaglutide left me miserable and I couldn't tolerate it. Switching was needed, but this works!

 

[Gym_Story]

This thread is old, but last summer I was frankly sick for months. I quit for twelve months and began again last week. A few days of nausea, then I could eat. five days in, gallbladder pain came back after some ravioli. I'll probably just quit and say I can't take the med, since I do not want my gallbladder out & it was the most painful thing I've ever felt. Best of luck!