SS-31 & MOTS-C: Should I stack?

Tons of opinions out there. Check out this thread: SS31 THREAD.

I've done a protocol that was 5mg SS31, five days on, two days off, for about a month. Then I overlapped it with MOTS-C for a couple weeks before stopping the SS31. Some people think 5mg is too low, or that SS31 is too pricey to use at a higher dose.

I felt like it boosted my overall supplement/pep strategy. @Calm Logic has posted a lot about this combo, too.

I'm on my second cycle of SS31/MOTS-C right now, and I think it’s worth it. Plus, I'm saving a boatload on groceries, haha.
 
When I searched earlier I didn't find anything! Then I found it by accident. Yeah, lots of different ways to dose this stuff.

Now to find the SS-31... MOTS-C is everywhere.
 
I love ss-31! I did it for 3 months at 4mg every night. I just felt more awake. And I'm 60-something.

Been on mots-c for a month at 5mg every other day, first thing in the morning. I started it during the third month of ss-31. Didn’t feel any extra difference. Going to add NAD+ soon.
 
Started Mots-C at 5mg daily, five days a week, but I paused to research SS-31. I'll start both together in a week or two.

Plan is 10mg/day for a month... using multiple 30mg kits into a 3ml pen.
 
I don't want to be a downer, but the human trials of ss31 weren't great. The mechanism makes sense, but it didn't work in humans like it did in the lab.
 
If you mean the MMPOWER-3 trial:

https://www.google.com/url?sa=D&q=https://ojrd.biomedcentral.com/articles/10.1186/s13023-023-02986-x

It showed some benefit in specific genetic subtypes.

Some human studies *did* show good results. Like this one on heart function:

https://www.jacc.org/doi/abs/10.1016/j.jacbts.2018.12.005

And this one:

https://www.ahajournals.org/doi/full/10.1161/CIRCINTERVENTIONS.117.005487

And a dog study showed benefits for heart issues:

https://www.ahajournals.org/doi/full/10.1161/CIRCHEARTFAILURE.115.002206
 
I meant studies DIRECTLY on humans, not just isolated cells, animals or in vitro. We looked at SS-31 in 2023 and couldn't find anything that confirmed success in humans. We only looked in some regions so maybe there are others we missed. I agree the mechanism is sound, I just haven't found proof of it working in real people. I'll check out that middle link, looks new to me.
 
There are a few out there. Do a search on Google Scholar or a science library. There was a study on people with mitochondrial myopathy, specifically an inherited form. It only worked a little, and only in people with a specific cardiolipin mutation. It also helped with eyes in another study, and also a fetus with Barth syndrome.

https://www.sciencedirect.com/science/article/pii/S2666914524001647

So it does *something*, just maybe not what we hope for.
 
Unlike many peptides, ss-31 has been through human trials. They just weren't successful in what they were trying to do. They weren't a total bust, but the improvements were small, especially when used for problems that weren't specific mitochondrial disorders. Think macular degeneration and heart failure.

This often happens with promising substances. This article sums it up well:
https://www.mdpi.com/1422-0067/26/3/944

The trials do show it's safe, with minor side effects.
 
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