Sublingual Semaglutide, huh?

[Morgan2000]

Hey everyone, has anyone ever tried taking semaglutide under the tongue? I've read it's possible with certain enhancers that help your body absorb it. I'm allergic to that benzyl alcohol, which makes using those multi-dose vials impossible, and I'd like to get around that.

 

[Snack-Progress]

I haven't, Morgan2000. But have you looked into those Orforglipron pills? I've seen them discussed. I hear they're becoming popular.

 

[Slightly_Smaller]

I know a lot of people in the UK use sterile water since they can’t easily get bac water. Maybe try that with your semaglutide? You can find pretty small vials, like 2 mg.

 

[Shannon_04]

It's not been studied well, so it's hard to say if it would even work.

 

[Reese_2007]

Those pills sound like a decent option.

If you want to avoid needles, intranasal might be more effective than sublingual. Nasal sprays are often used for peptides. I recall reading a research study on using nasal insulin for Alzheimer's treatment. But proceed with caution. You'd have to research the dosage. Start with a very low dose, as it may absorb faster than regular subcutaneous injections, possibly leading to more nausea. The brain may also receive a higher dose than intended with injections.

Alternatively, buy 5mg vials of semaglutide, use a single dose, and discard the rest. Use plain water for the injection. It ends up being pretty inexpensive, about $5 per dose.

I'm allergic to that benzyl alcohol

It's actually possible to be allergic to benzyl alcohol, even though it's a small molecule!

 

[Slightly_Smaller]

Important note: when I said 'plain water' I meant sterile water, NOT tap water!

 

[Hank_2002]

It really depends on your goals.

My doctor told me sublingual administration isn't as effective for losing weight compared to subQ injections, and it won't help much with diabetes.

 

[Kelly1976]

I'm curious about these new oral GLP-1 meds. I saw something about a Rybelsus being approved recently. Supposedly, it has special tech to help with absorption and comes with specific dosing instructions.

 

[Morgan2000]

Thanks so much for all the replies! I'll def look into the nasal spray idea, Reese_2007, but the sterile water + single use vials seems like the easiest first step for me.

 

[Snack-Progress]

I agree

intranasal might be more effective than sublingual.

I've read some interesting research on peptide absorption through the nasal passages. Definitely worth digging into the science before trying it though!

 

[Reese_2007]

Just be careful everyone. I saw a reminder that it's against the rules to talk about or try to sell non-approved medications, including by private message. There are lots of sources out there, so be careful what you buy.

 

[Fox_Buddy791]

Got contacted for a pregnancy study with this med after being on tirzepatide before. Got pregnant within weeks of stopping. Women with diabetes take their meds in pregnancy, so it makes sense they're researching this too.