Switching from tirz to Reta/Cagri - advice?

M

Mel57

Well-known member
Tried tirzepatide, and it worked great at first, but then it kinda stopped working, even when I kept upping the dosage.

Was taking up to 10mg of tirzepatide a week.

Even went as high as 12.5mg and then 15mg.

Honestly, it didn't really do much for me, even though it did initially.

Just bought some reta and cagri.

What dose should I start both of them on?

I must have a high tolerance because once I started tirz, it worked great at first but then stopped, even when increasing the dosages.

Any advice?
 
Start low and go slow to avoid any bad side effects. Ask a chatbot what the best starting dose is; it can even help you plan your week-by-week increases.

Also, I'd stop the tirzepatide before starting. I'd even wait a few weeks to let it clear out of your system if you were on 15mg tirz.

Just a heads up, you might gain some weight during that period, but don't worry. You'll lose it and more once the Reta starts working in a month or two. You got this!
 
Reta with cagri is something I'm considering too, since the cagri might help suppress food cravings until the reta dose is high enough.

Regarding switching, I don't think a washout period is needed since the starting doses will be low anyway.

A search engine suggests starting at 0.25 mg/week for cagri (when taken with a GLP like sema, but it would be reta in this case) and starting at 0.5 to 1.0 mg/week for reta.
 
Maybe you could try microdosing Reta to get over the hunger hump before you start stacking peptides? Microdosing will let it build up in your system faster than dosing once weekly. (Reta has a half-life of nearly a week). You could also start with a low dose on your first injection (1 mg) and increase it gradually on the next few injections as long as you don't get any heart palpitations. Remember, Reta isn't tirz. You don't know how you'll react to it. When you start it with cagri, you'll never really know what's doing what.
 
I microdose Reta and like it better than injecting it once a week. I'm still on a lower dose and taking it slow (because of the potential side effects), but I haven't had any problems and I've started feeling a difference. I've been on Reta for almost a month now, microdosing for 3 weeks.

Of course, do your homework and make sure the benefits outweigh the risks for you!
 
I posted about my experience switching from T15 to Reta & Cagri on another site, and maybe here too. Started Reta at 1mg and cagri at .125mcg. I started the Cagri first while on T15 for about 5 months, going down to T10. Once I got to T10, I started Reta 1mg the next week (and stopped the Tirz). There are lots of different ways people are experimenting, so it's hard to say what will work for you. Now that I'm in maintenance, I can get good baselines because I have more flexibility.
 
Thanks for the replies everyone. I think I'll try the microdosing Reta approach that @Metabolic_Mitch suggested. Seems like a good way to ease into it. Gonna start low and slow. What do you mean by 'food noise hump' exactly?
 
Just saw this thread and wanted to chime in. I've been following Dr. Mark Scholz's discussions on semaglutide. He seems pretty impressed with its potential for weight loss but also stresses the importance of understanding the long-term effects and potential risks.
 
Mel57 said:
What do you mean by 'food noise hump' exactly?
Click to expand...

I believe @Metabolic_Mitch is referring to that constant, nagging feeling of wanting to eat, even when you're not physically hungry. It's like your brain is constantly telling you to eat, and it can be really hard to ignore. Cagri is often used to reduce that.
 
Sorry you're dealing with this. Got solid pointers from others you could test. Sema's known for rougher sides lots of people. If nothing works and you still feel bad maybe tirz - tends easier for people versus sema. Low sema dose means if nothing helps, tirz might click. Try suggestions first and check. Just my thoughts. Rooting for you. Good luck!
 
Treat Tirz as a tool not a miracle. You said you eat while full - that's you, not the med. Try Cagri and you'll nearly hate eating without trying but that's usually not the goal.
 
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