Hi all. Two years-plus on this now, and Reta has taken 34 kg off me. Tirz came first, topping out at 7.5 mg, then I changed drugs, and right now my weekly maintenance shot is somewhere between 2.5 and 5 of Reta. Has anyone had loose stools along with it, and what helped you? It keeps getting named as a likely problem. Apart from that I feel good, except my skin got touchier and more reactive to everything around me, which is new.