Switching from Tirz to Reta...worth trying?

I

Inject-Dude

Well-known member
I've been on tirzepatide for about 14 weeks, and I'm hitting some walls that are making it hard to get to a good dose. I worked up to 5mg weekly. Around day 3 or 4, I'd get hit with awful diarrhea and some sleepless nights. Initially, I thought the GI issues were from something I ate out. But it happened again after my next dose. The insomnia might be anxiety-related, and maybe I could deal with it over time. But the other issue is just too much. So, I've dropped back to 2.5mg tirz, split into two doses per week. It's helping with the food noise a bit, but not enough. I'm thinking about switching to reta because the effective dose seems much lower. Hoping I get the benefits without the bad side effects. Any thoughts from you reta users? Is this a realistic idea, or just wishful thinking? Any advice is appreciated!
 
I haven't used Tirz, but had similar issues with CagriSema a while back. How's your water and fiber intake? Is your diet good? Are you exercising? There are a lot of things that can cause what you're going through before you switch meds. Like @Clean_Journey said, maybe just try a small amount of Reta first to see if it is any better for you.
 
Obviously, this is your call. Everyone's different.

Sounds like you want:

* Less GI issues
* Less insomnia
* Reduced cravings
* Less food noise
* Lowest effective dose

The food noise reduction might not happen at low Reta doses. Since you've been on tirz, you might need more Reta (above 2-5mg) to see any effect. GI issues could be better or worse. Split dosing might help there (like you're doing with tirz), and start low on Reta. But that might mean more food noise and less suppression.

Many users who've tried both say Reta can raise resting heart rate and cause insomnia, even in people who didn't have it on tirz.

If you try Reta, be patient. For the best results, let the tirz clear your system before switching. But few people do that. This is the advice from GLP-1 prescribers when switching. There's no advice for Reta switchers. Tirz takes time to leave your system, so remember the overlap with GI symptoms.

Everyone's different. Reta might be great for you, but weigh the pros and cons. Some things you can only learn by trying.

The effective dose matters. It has to work for you.

Studies say 15mg tirz is most effective, but I lost most weight on 5mg and should have stayed there longer. The Reta study upper dose was 12mg, but effective between 4-8mg when balancing side effects.

15mg tirz plateaued me. I lost nothing for months. Reta didn't work for me (weight loss) until 6mg. Now it's working! 🙏

I hoped to stay at 2-3mg Reta when switching, so I get your thinking.

Didn't work for me. But it could for you! Some super-respond to Reta (0.25 and 0.5ml giving effects), but they might not have tried other GLP-1s (maybe not, there are always exceptions).

Good luck with your choice! Hope you find the right fit. 🎯
 
I started higher than that, but I've seen people say they respond well to super low doses, but they are usually new to GLPs. You may need more since you've been on tirz. Listen to your body!
 
Clean_Journey said:
I saw someone on another forum mention they were only 21 and started feeling the effects at 500mcg every 3 days but then it stopped working when they changed to 1mg a week, so they are going to split the dose like PurePal said.
Click to expand...

Yep! That poster may also be underdosing or have a bad batch, but split dosing is always a good idea. Especially with Reta.
 
Most people switching from 8mg tirz to Reta start around 1-2mg Reta weekly and titrate from there - the mechanisms overlap enough that the appetite suppression carries over, but the fat loss velocity often shifts. Fourteen weeks is long enough to have a real baseline for comparison.
 
You must log in or register to reply here.
Back
Top