Switching meds - Reta + Tirz?

Hong Kong Yanpep International
I deal with that a bit on just tirz, but I figured it's from losing so much weight and my doctor hasn't dialed back my blood pressure meds enough yet.
 
took april off, gonna restart first of the month. just got tired of it. high dose doesn't mean you break through the nausea. had a vacation and wouldn't have been on it anyway. not really losing either. gonna start back at 4.8mg or dial it down more if needed.
 
The HR uptick on reta while on afib meds is worth a specific check with your cardiologist. Most have a clear view on GLP-1s by now.
 
Starting at 4mg Reta while stepping Tirz down to 7.5mg and titrating from there is a structured cross-over approach. Evaluating monthly at each stage gives you a clear timeline rather than reacting to week-to-week fluctuations. What's driving the decision to potentially stay at the combined dose rather than fully transitioning?
 
Dropping from 7.5 to 5mg due to injection site reactions and then adding Reta on the same day as the Tirz dose is worth monitoring. Running them same day loads the sides all at once. Spacing them a few days makes it easier to know what each one is contributing and manages the side effect timing better.
 
The 7.5mg Tirz to 6mg Reta switch with just 2 days of mild nausea is a clean transition story. A new Reta source while still on 2mg Tirz is a different situation - less tolerance built and the combination at current doses is already working. What's the goal for adding Reta - more suppression or bridging toward a full transition?
 
Spent roughly the first year on Tirz splitting doses across three shots. Started mixing things up more recently, working Reta and Cagri in as needed.
 
Curious how this went for you, did you start with one and add the other later, or the reverse, or just launch straight into running both together?
 
Hey all. Spent roughly six weeks on Reta and it worked beautifully. Switched over to tirz mainly for the cardiovascular upside, starting the standard 2.5mg entry dose. First week hunger wasn't much of an issue, unlike how Reta felt. Did dose two yesterday and today I'm hungrier than I've been since before starting Reta originally. Not sure if leftover Reta was still active in my system last week or not, but the hunger today after dose two is intense. Got the tirz from someone here with a solid track record, so I doubt it's fake, just seems like something's not clicking the way Reta did for me. I'm sure Reta offers similar cardiovascular benefits too, would just love to see that actually published somewhere. Anyone run into something similar?
 
Reta plus Tirz has plenty of anecdotal support behind it. Working well for me : )

You'll obviously have to experiment some to land on the right doses for your body. Good luck!
 
All you can genuinely conclude from feeling nothing at 2mg reta across four weeks is that you're not an unusually strong responder. Sure, most people notice something at that amount over that timeframe, but far from universal. Given zero side effects or benefits showing up at 2mg, moving straight to 4mg carries pretty minimal risk of serious problems, and continuing upward makes sense even if effects stay absent, though that's genuinely unlikely.

Don't know your reason for starting reta, extra weight? severe obesity? Diabetes management? But if you're committing to this, give it a real shot, working up to around 12mg with bumps every four weeks. In the unlikely case you turn out to be a true non-responder, roughly 5-15% see minimal loss, at least you'll have certainty, and switching over to the other compound is unlikely to change much. Might need to look at a different mechanism entirely at that point.
 
Ran the entry amount of reta across the first week, then jumped straight to 4mg, meanwhile cutting the other compound in half and holding it there.
Could try Monday at 1mg then Tuesday at 1mg, stepping up by 1mg and eventually consolidating from twice weekly down to once. Keep the original pin on the same weekday and schedule the new one three days out from that.
Currently doing 4.4 on the newer compound Sundays and 5.5 on the original Tuesdays, weekly.
 
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