VipRoids
Active member
I keep watching competitors celebrate twenty pound drops on GLP-1 agonists without asking the one question that matters. What percentage of that was muscle. Because the published trials answered it, and the answer should worry anyone who lifts. In the landmark semaglutide and tirzepatide obesity trials, researchers measured body composition with DEXA, and a substantial share of total weight lost was lean tissue, not fat. The phrase the researchers used repeatedly was that lean mass loss was greater than what would be expected from diet-induced weight loss alone.
The mechanism is not mysterious. These compounds suppress appetite so hard that protein intake collapses unless it becomes a deliberate project. Someone who struggled to eat enough protein before now eats half of it and feels no drive to fix the deficit. Throw in reduced training drive and you have the perfect recipe for losing the exact tissue you spent years building.
The uncomfortable part is that bodybuilders are now using these tools during prep, telling themselves the anabolics will protect the muscle. Maybe. Maybe not. Nobody has run that study. So here is my honest question to this board. Has anyone actually done a DEXA scan before and after running one of these compounds while on cycle. Not how you looked in the mirror, not how strong you felt. Actual scans. Because everything I read here is vibes and the data that exists publicly is not gentle.
The mechanism is not mysterious. These compounds suppress appetite so hard that protein intake collapses unless it becomes a deliberate project. Someone who struggled to eat enough protein before now eats half of it and feels no drive to fix the deficit. Throw in reduced training drive and you have the perfect recipe for losing the exact tissue you spent years building.
The uncomfortable part is that bodybuilders are now using these tools during prep, telling themselves the anabolics will protect the muscle. Maybe. Maybe not. Nobody has run that study. So here is my honest question to this board. Has anyone actually done a DEXA scan before and after running one of these compounds while on cycle. Not how you looked in the mirror, not how strong you felt. Actual scans. Because everything I read here is vibes and the data that exists publicly is not gentle.