Tired after upping Tirz dose - anyone else?

I almost quit the first couple weeks because of the side effects, but it leveled out by week three. I'm glad I stuck with it. Find a good "Mounjaro buddy" like a ChatGPT bot, or a friend. It's been super helpful to manage some of these moments. They offered me a few good tips how to handle side effects, what to do, and helped with my food.
 
felt kinda nothing at low doses, then hit some fatigue when i bumped up. but weirdly the higher dose didn't make me as tired? maybe just adaptation or whatever. appetite suppression was intense for a bit though, like a protein bar made me feel sick. wore off after a couple days and then i was back to normal eating. still not sure if the whole thing is worth the hassle for me.
 
I thought I'd gotten past this one but after a few months the tiredness caught back up with me. Been trying papaya enzymes at night with no luck so far. Does anything actually help? It just makes me feel pretty crummy.
 
yeah with tirz dosing like that, 15mg every five days does work out to about 21 weekly. if youre looking to bump it i'd probably go 17.5 weekly first, then 20 if thats not doing it. at the higher doses the jumps dont matter quite as much anyway
 
wow that's incredible, great work on all of it. i started eating carbs again after four months on tirz too like rice and pasta and bread. i prep sofrito rice on sundays for the whole week and let it cool before reheating, supposedly that helps with how your body handles the carbs or something. not totally sure if it's legit but i do it anyway. congrats again on crushing it.
 
I've dealt with food poisoning before. But nothing compared to tirz - the diarrhea got so extreme I blacked out from blood pressure tanking and couldn't even stand when I came to. I managed to call 911 from the floor. The ambulance crew got me hooked up to saline and things improved real quick. Turned out I'd lost consciousness and cracked my face on the toilet paper holder during the fall.
 
my eating's solid, mostly vegetables, good protein from meat and beans, prenatal vitamins so my hair doesn't look trash. the tirz is what's draining me and i'm honestly okay with it. been stuck to that pattern far too long watching myself creep up and up, hitting the wall my dad did back in september, knowing he was gone twenty years after he hit my weight, buying new clothes every time, dealing with all that. i'd rather feel worn down right now than live like that. lots of folks say it fades with time. the other med i tried did help cut the exhaustion down some, so there's hope.
 
Been doing Tirz for 2.5 years myself. Even the starter dose messed with my sleep and I deal with other side effects too. First couple days after the shot are rough but then settles down. Take a ton of sleep meds that still get affected. Trade-off though - lost 50 pounds and kept it. Worth the rough nights.
 
Been on Tirz for over 2 years now and my anxiety basically went away about 2 weeks in. Was dealing with serious stuff before that kept me up at night. I'm way more relaxed now. Did anyone else experience something similar, and what happened to your anxiety if you eventually stopped the medication?
 
Got this diagnosis a while back when blood work showed elevated ALT. The ultrasound tech said it wasn't severe compared to others, so I kind of brushed it off. But honestly that's probably not the right way to think about it. Would be interesting to get another scan down the road once I'm further along. Good to hear you're moving in a better direction.
 
I've had solid results on Retatutide but hit a wall around max dose where the appetite suppression kind of faded and the scale stopped moving, though I did manage to hold steady. Switched to 15mg Tirzapide and it's been similarly quiet so far. Have you heard of anyone cycling the dose down to maybe 5mg for a stretch, then ramping back up to reset the effect? Seems like some people approach it that way instead of fully stopping and restarting. Curious if that's something folks here have had luck with.
 
congrats on the work. if 15mg works better for maintaining, maybe stay there? staying on it has health perks outside of just weight loss.
 
those doses sound really low. i did 500mcg of bpc-157 twice a day plus 2.5mg tb-500 on monday and thursday and it fixed my golfer's elbow and shoulder stuff i kept reinjuring. found the protocol online and stuck with it.
 
stacking Mots-c at 2mg daily with 5-amino 1mq at 2.5mg daily for 12 weeks. I'm 59, went from 217 to 190. strength's solid—bench near 300, went from 2 pull-ups a year ago to 15 yesterday. thrilled.
 
Found some solid posts online about dosing that. One guy said his doc gave him 50mg to split and take at night—total game-changer for sleep without Ambien hangover. Another cut it to 25mg because the morning fog was too much. Both swear it worked way better than sleep meds.
 
7.5 hits the sweet spot for me. first dose was gnarly but my body adjusted. food noise doesn't really come back until the day i pin, which is fine. lost weight through discipline before but always fizzled around month four, so one food day a week is way better. was dropping 3.5 a week before—too fast. slowing it down now.
 
Two years here doing this and some days I still can't believe it works. Lost a good amount and maintenance keeps things steady. Diarrhea hit me rough at first too - took a while to figure out what helped. Skin changes are real, but the tradeoff of feeling better and moving easier makes it worth it.
 
This resonates with me. I've watched people chase the next thing instead of letting their current dose settle. You're already seeing results at 5mg - that's the real marker. I trust the slower approach more than constantly upping. Plateaus feel frustrating but they're normal. Give it another month and reassess. You might surprise yourself.
 
not sure why your doc won't increase the dose. at 5mg there's no reason to add something else instead of just going up. that's a first for me honestly. if you're still losing, stick with where you're at - a plateau is a full month with zero change. you're not there yet.
 
February to mid-April and dropped 40 pounds doing split doses twice weekly on both compounds. Titrated each one slow across different weeks so nothing hit too hard at once. Right now testing Reta solo to see what satiety looks like on its own. If it stalls I'll layer Tirz back in low but the single-agent approach felt worth trying first.
 
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