Tirz appetite suppression TOO strong?

B

BearDone

Active member
Hey everyone,

I recently got some tirzepatide and I've taken 5 weekly doses. I started at 2.5mg, even trying half that amount, but the appetite suppression is intense. As a (retired) physique competitor, I prioritize food and macros, so this is challenging. I feel queasy from hunger, but I just don't want to eat; the thought of food makes me want to throw up. On non-lifting days, I struggle to eat 900 calories.

I've also had adrenaline rushes, which probably worsen the suppression. My resting heart rate went from the mid-50s to the low-60s, and sometimes it's over 100 just from taking the stairs or feeling anxious. This is new and, as someone with health anxiety, it's not fun.

I chose tirz for its appetite suppression, hoping to curb binge eating and lose weight. I haven't even finished one vial, and I have more. I'm thinking about switching to Reta, but I don't know what to do with the rest of the tirz. I'm not sure how much longer I can deal with the adrenaline dumps. I feel uneasy most of the time.
 
Maybe do a little more reading? A slightly elevated HR is a pretty common side effect from these meds. Reta definitely does it too, I think its part of the 'extra burn' effect. Reta is loved by bodybuilders but go in knowing it WILL raise your HR.

They're all GLP-1 receptor agonists, but that's not the whole story. The molecule for tirz and reta is more than just that. They're tinkering with these molecules and it's interesting to watch.

I don't know much about the adrenaline dumps. Sorry. Anxiety can be chemically driven… maybe it will improve as your eating stabilizes.

Lower your dosage. Big side effects means lower dosage. Researchers landed on 2.5mg as a starter and 5mg as 'therapeutic' because they had to balance side effects with good results. If 2.5 is too much then...it's too much. Some people stick with 2.5mg and get results.

These drugs take a month to build up in your system. If you want to reduce side effects, skip a week, then restart at half dose. This lets some of it clear out, then you can maintain lower levels.

There are blood level calculators online. They show a graph, and you can see that it takes 4 weeks to build blood levels. The graph shows why jumping from 2.5-5mg and 5-7.5mg sucks for some people: the big spike causes fresh side effects.

Put in your doses and see why the one different dose didn't help much.
 
Thanks for the reply. I know about the increased heart rate, and I don't really mind it. It's the adrenaline dumps that are the problem. I'm going to try spacing out the injections at half the 2.5mg dose and see what happens.
 
Dude, those aren't "adrenaline dumps." It's just tiredness and low energy. It's from drastically cutting calories and from the peptide itself. Pretty much everyone on Tirzepatide feels it at some point.
 
Your dose is too high. Halve the lowest dose you tried, either by injecting less or spacing out injections more.
 
I had the same issue with appetite suppression in the beginning. It does get better as your body gets used to it. I also started craving sweets like crazy! I used to be all about savory foods, but now all I want are protein shakes, greek yogurt and fruit! I think my body is just craving the sugar because of the calorie deficit. Maybe try some sugar-free creamer in your coffee? That helps me sometimes.
 
Thanks @Bug_Buddy, I'll try the sugar-free creamer! I've been trying to force down more protein, but it's a struggle. Maybe the shakes will be easier. I've never been a sweets guy, so this is really weird.
 
Congrats to everyone having success! I've gone from always having a belly to actually seeing some definition! It's only been like 10 weeks and I'm a different person. I look at food so differently now. I WANT to eat good food, and I WANT to exercise. My blood work is better than ever too!
 
I was ramping doses to chase that appetite suppression feeling, but after two years it's pretty much gone. Kept myself healthy through that time, but I'm not sure if it was smart long term. Happy where I'm at now and testing if I can taper without regaining. Could go either way - might need it on and off forever, or I might pull through clean. We'll see.
 
It really varies. Trial groups started at 2 mg, you could try that. My appetite suppression didn't kick in until 6 mg, now at 8 mg it's stronger. Takes time to build up in your system.
 
Should mention the person's also on Tirzepatide, 7.5mg a week. The appetite control and better insulin response are coming from the GLP side of things, not anything else.
 
I've read that belly injections give stronger appetite suppression, though I can't cite the source. Rotation still matters to avoid lumps. Did try Semaglutide, Ipamorelin, and others - arm and love handle hits give decent variety.
 
How intense was that first week for folks starting at 2.5mg? Did appetite drop like a ton or was it subtle at that lower dose? Any side effects? Just hit 2.5 and I can barely finish what I serve myself. No cravings, no snacking urge, nothing unpleasant. Seems normal enough. Does tolerance build so people need to increase, or can someone stay here?
 
The 1.2g/kg ceiling at higher suppression doses is a common friction point - many people find that splitting protein across 5-6 smaller opportunities throughout the day rather than trying to hit it at 3 meals closes most of the gap without requiring appetite that isn't there.
 
The cold flashes on tirz don't respond to bundling - they pass in a few minutes on their own. For suppression this intense, the physique competitor background is the advantage: macro-tracking applies even when hunger signals go completely quiet.
 
The fat oxidation pathway is what makes Reta feel different - the deficit happens through an additional lever, so the appetite signal doesn't need to be as aggressive. Worth the comparison for anyone finding tirz suppression overwhelming.
 
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