Tirz concentration... too high?

Gene_Sis

Gene_Sis

Well-known member
Hi everyone,

I'm planning some research using a product and trying to figure out the concentration to make sure it's safe. The vial doesn't state the liquid volume. If I assume it's about 3ml in the vial, I could add around 2.4 ml of bac water. That comes out to 25.00mg/mL. Has anyone researched at a concentration that high? I thought Tirzepatide was around 5mg/ml. Anyone suggest adding more BAC to dilute it or is 25.00mg/mL ok?
 
I believe those vials do hold 3ml.

The dose you're currently using should determine how strong to make the concentration. I personally don't want to inject a whole ml for one dose. It can be done, but I'd rather my max dose be around 0.50ml.

If you added 3ML of water to 60mg of the peptide, then a 5mg dose would only be 25 units on a syringe.

Use a peptide calculator to figure out what works for you. I've had luck with this one https://www.xcelpeptides.com/peptide-calculator/
 
That's not quite right. The commercial injector pens all have doses in 0.5mL of liquid. So the 15mg pen contains 0.5mL, which puts the concentration at 30mg/mL. https://www.medicalnewstoday.com/articles/drugs-zepbound-dosage

Injecting more than 1.5mL under the skin can hurt. https://pmc.ncbi.nlm.nih.gov/articles/PMC6822791/

I usually aim for ~1mL of bac water in each vial, no matter the amount of tirz in the vial. I always start with the number of units I want in mind (on my insulin syringe). And I always consider what my next dose up will likely be so that it's also an easy number to find on the syringe. I use the reverse calculator that's linked in my signature.
 
So, if I get this right, a higher concentration is better because you inject less liquid? Is there a limit to how concentrated I can make it? Like, could I use only 0.5ml of BAC water?
 
I try to keep my injection volume low, too. Less chance of pain or a bleb under the skin. But make sure the powder fully dissolves. If it's not dissolving, you'll need more diluent. Don't want to inject undissolved solids!
 
I've always stored my peptides in the fridge as soon as they arrive. I don't want to risk losing any potency.
 
Gene_Sis said:
I'm wondering about proper peptide storage. Since it's a water-based peptide, does anyone know if I should keep it refrigerated even before mixing with BAC water?
Click to expand...

Yes, refrigeration is key! I stick all my peptides in the fridge as soon as they arrive. Why risk any degradation?
 
I went through something similar. Started semaglutide, got up to 1.5 mg but the side effects were brutal. Dropped back to 0.75 and tried adjusting but hit a wall. Took a month off to let my body reset, then switched to tirzepatide. The loading dose didn't budge the scale, but once I hit 5 mg on my second week I started seeing results - lost 3.2 kg just in that stretch. Overall shed 14.9 kg on semaglutide before making the switch. For me, tirzepatide quieted the hunger signals and killed the binge urge without the nausea that semaglutide gave me, so the effect feels less extreme but still works.
 
I run the 8mm and still get reactions - my concentration's probably too high around 12mg/ml from the active component. Dropping to 6mg/ml next time to see if it helps.
 
Got no plantar fasciitis this winter which is surprising since I'm not doing anything different, just on 12mg tirz now. Started last March. Lost weight sure, but the anti-inflammatory benefit might be doing the work.
 
Concentration math without stated volume: weight the full vial, subtract the empty vial weight, and assume 1g/ml water density to get volume. Most standard Tirz reconstitutions run 5mg/ml or 10mg/ml depending on the vial size.
 
You must log in or register to reply here.
Back
Top