Tirz is changing my life!

Hong Kong Yanpep International
BP at 120/80 from 140/95 with the snoring gone and resting pulse in the 40s is the cardiovascular package - those markers landing together usually means the autonomic effects are matching the weight change.
 
The pre-workout mental game to actually get there is real - that external push to start even when you don't feel like it. The results on BP and pulse are strong, those cardiovascular markers tend to respond faster than people expect.
 
Currently running 300 test, 2iu of growth hormone, and just moved over to Tirz after Reta pushed my pulse up way too much. Feeling good today, might throw in some Tren later.
 
Appreciate it! You're right, tirz has been great for me so far, and I'm not changing anything besides titrating up and keeping close tabs on weight, intake, and activity going forward for a good half year.
 
Heart rate dropped by roughly twenty beats each minute, and pretty much overnight too. Genuinely enjoy watching that steep downward line on my phone's health tracking app. Stayed consistently lower ever since too.
 
Running something similar, though my Tirz is higher and Reta lower.

12mg every six days on Tirz, 4mg every six days on Reta, 2mg every six days on Cagri. Landed on this combo after a rough bout of ear ringing and skin sensitivity hit when I bumped Tirz from 7.5 to 10 a few months back.

Since then I've climbed the tirz to 10, then most recently 12. Hit a stall I can't break through. Only three weeks into this newest combo, so still early to judge results. Just 7lbs from my target.

Began with a BMI of 40.0, aiming for something in the high 20s. Under 30 puts you in overweight territory instead of obese, that's my current goal, my third one so far. The first two targets came easily just running Tirz solo, I really underestimated how well this would work!

Down 55lbs total since starting Tirz seven months back.
 
Previous update from around five months in:

Five months in, down a solid amount. This medication's amazing. Blood pressure's normalized after previously running high. The nightly snoring's vanished entirely. Pulse now sits comfortably in the lower range. Lost this same amount of weight several times before, always rebounded eventually. Finally feels sustainable this time. About ten more pounds to reach the target, also...
 
Right there with you! At 2.5 Tirz, still dropping. Next shot I'm pulling back to 2mg. If it keeps working I'll start spacing the doses out. Can't afford to lose any more! Got some Reta sitting around but my heart rate didn't handle that one well. Otherwise I've got a huge Tirz supply saved up, so landing on the right amount of Tirz is really the goal here. Stopping Tirz altogether just isn't happening, refuse to let that mental chatter about eating come back.
 
That energy boost is great! Goal weight came on a pretty low tirzepatide dose and the perks outside weight loss are so big I don't want to stop. It did flatten me slightly, though not badly, and I could tell that'd be hard over time. So I added reta 1 mg weekly, dosed 72 hours after tirz, starting at .5 in case of a reaction, and it was obvious right away that it helped. I'm clearly a super responder, pure luck. The 1 mg of reta lifts me nicely. Hydration and constipation need extra attention, so I down 32 oz of water right after waking. I did not notice my heart rate going up, but maybe that explains the energy?
 
Took my heart rate and blood pressure one afternoon this week to compare, 101/68 and 68. Pretty happy with that. Doing the afternoon reading later since today's pin day. Reta is interesting. I reached goal at 10mg several weeks back, then dropped to 6mg for two weeks and 8mg for one, and I'm holding steady, moving 1-2lbs weekly. I feared I'd keep dropping. My point: staying on one dose may just plateau you, which is why we actually titrate up when a dose stalls. Who knows, that's my two cents from a small brain.
 
I switched three days ago. Reta went in at half strength, then two weeks passed before the tirzepatide. My reata dose was just 2.5mg, yet even the half dose carried well into week two. I disliked the higher heart rate and lower HRV and figured Tirz could get me to my goals. So far so good, since it is crushing my appetite and my Garmin is not sulking.
 
Tirz I can't judge, Reta I can. One month of it took off plenty of weight and ended my nightly snoring entirely. I've had no sleep study since, but rest is far better with no snoring to wake me. Whether the drug does it directly or the weight loss is the main driver is unclear, but I give reta the credit.
 
perkycoasting60 You've achieved almost twice my weight loss in a similar timeframe. I'm on tirz too but I'm sure your effort doubled your results, since I've been sedentary with other health issues & ankle trouble, only today did I start moving with purpose again. I personally was lucky that my sleep apnea went away in the initial week on tirz, and all my labs improved.
 
Glad your numbers are trending right. Watched closely myself, wearing a Garmin to track shifts. Used to be pretty muscular and lifted heavy, stopped once I got sick that December. Heart rate spikes easily though blood pressure stays fine, my heart compensating. Started a betablocker in May for that. Semaglutide came first, but insurance capped me at 1mg, pushing me elsewhere. No exercise plus the betablocker means metabolism's slowing, family history isn't pointing anywhere good either. Haven't told my doctor about switching GLP1s and raising the dose, dealing with that later. Heart rate is why I stick with tirz over reta, easier there. Hoping, like you, to slowly build tolerance as weight drops. Started around 123kg in April 2024, likely genetics, autoimmune issues, and other meds.
 
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