Tirz or Reta First? Help a Bro Out

T2D_Survivor_Mark

T2D_Survivor_Mark

Well-known member
Not Asking for Medical Advice
Asking for personal perspectives only

Hey everyone,

For those who've been using GLP-1s to lose weight, if you could do it all over, would you start with Tirzepatide or Retatrutide? I'm leaning towards Tirz first, then maybe Reta later. Someone suggested I "keep my options open" in case I plateau on one. I get that everyone's different, but I'm just trying to get a good starting point.

Also, what do you think about adding something like Amino 5 1 MQ when starting a GLP-1? I've heard it can help prevent muscle loss, even though I'm already working out and doing cardio.

I've been overweight forever. My metabolism sucks. I've already dropped 50+ pounds with diet and exercise, but I can't seem to lose any more. Thanks for your thoughts!
 
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If I could start over I would try Semaglutide first. It's cheaper, and after being on Tirz it doesn't seem to do anything for me. Sema, then Tirz, then Reta would be my order.

Also, I wouldn't start multiple peptides at once. Try one, see how it goes, then add another if you need it.
 
I'd begin with Reta, especially if you're new to GLP-1s. I've found it works well and has fewer side effects compared to others. I started with Tirz, but stopped after about a month because of constipation, insomnia, and lack of enjoyment. Reta hasn't given me those problems, and my weight loss has been faster.
 
I think Semaglutide first, since it's the least expensive and has the most side effects (which, for some people, helps it be more effective). Then Tirzepatide, and Reta if needed. That way, you have more options if one stops working.
 
I chose to start with reta myself. I did experience some side effects initially, but they disappeared after switching to microdosing three times a week. Two months in, and I'm only at 3mg, split into 1mg doses on Monday, Wednesday, and Friday. Sometimes I deal with minor food cravings, but I'm okay with that. Eventually, we all have to learn to eat without the extra help. On days when cravings are stronger, I usually realize I haven't had enough water or fiber. I see GLP1s as a helpful tool, not something I can't live without.
 
Sema then tirz. I dropped about 33 pounds on sema, going from 194 to 161, with a max dose of 1.0mg. It was a gradual process, but it worked. Then, I maintained for a bit, which gave me time to adjust. I switched to tirz a month ago, and I'm currently at 3.0mg. I plan to microdose until I reach 145 pounds. I'm interested in trying reta, but the heart racing side effect makes me nervous.
 
I don't think we can really answer this without knowing your goals, risk tolerance and budget.

I picked reta as my first GLP--because I wanted the best performance. Appetite suppression isn't really my thing. It's not "food noise", it's that I eat big portions when I do eat.

And remember, reta isn't even a real FDA-approved drug. The data looks good, but how do you explain this to your doctor? Even a chill doctor might tell you off for using some underground peptide instead of approved sema or tirz
 
My usual RHR is around 80. That's really scary to have it jump that high
T2D_Survivor_Mark said:
I initially chose Reta, but I got that dreaded Resting Heart Rate increase (went from 68 to 120!), so now I'm happy with Tirz.
Click to expand...
 
Yeah, it wasn't fun. Something I was told to try after a few weeks on Tirz was to add 1mg of Survo three days after each Tirz dose. Apparently, this adds more GLP-1 and Glucagon, making it work similar to Reta without the heart issues, and it also helps with the food cravings. I'm pretty happy with it so far. But keep in mind, one-size-fits-all doesn't really work here.
 
Sema did nothing for me except cause constipation. Tirz was okay, but it made some foods taste weird – coffee, steak, tomatoes. I ended up living on protein shakes and supplements. Then I found out about Reta. Now I can enjoy my coffee again. Steak tastes great. Salads are fabulous!

Though, I still have to make myself eat. Nothing really sounds good. It's great when I actually cook something, but I just don't feel like it... except for coffee. I love my coffee.

So, to answer your question, Reta. If it doesn't mess with your heart, it's the way to go. And start a bowel regimen *before* you have a problem, okay?
 
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