Tirz + Reta or Cagri... or split dose?

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PulseDonut36

Well-known member
I'm on 6mg of tirzepatide each week, but dealing with pretty bad nausea. Anyone tried stacking retatrutide or AOD and had good results? I like the idea of retatrutide since it's not a daily injection, but honestly, the jabs aren't that bad. I'm also thinking about splitting my tirz dose since I notice the food cravings coming back around day 5. I used to have zero cravings on 3mg. Maybe 3mg every 4 days would be better? What do you all think? If you've stacked Reta with your tirz, what kind of schedule did you use? Did you see better results?

there's a solid retatrutide dosing and stacking breakdown thread if you want the full rundown
 
Maybe try splitting your weekly tirz dose. I was on 10mg when I started splitting (now I'm up to 12.5mg). It helped keep my appetite in check and reduced food noise throughout the week. I'd take half my dose every 3-4 days, so smaller doses twice a week might also help with the nausea.
 
Before you jump into stacking, maybe experiment with split dosing of your tirzepatide first. See if that solves the problem before adding another medication.
 
I'm at 10mg tirz and by day 4-5 after injection I feel the effect fading. Really hungry by then. Been at this dose for about 1-1.5 months and still need to drop 60-70 more. Should I go higher or try multiple injections per week instead?
 
Stacking a little bit of retatrutide (2.5mg) with tirzepatide (7.5-20mg) didn't really work for me. The retatrutide seemed to be doing all the work. I switched to Reta completely and it suppressed my appetite a bit better and the side effects were noticeably better, especially constipation. If you're dealing with food noise, maybe add a low dose of cagrilintide a few days after your tirzepatide dose. I was shocked when I added it to my high-dose reta. Cagrilintide is amazing for me at a low dose. Other weight loss peptides needed a high dose to kill my cravings. Cagrilintide is better than Tirz or Reta for this. It's as effective as Semaglutide, but without the side effects. It also lasts longer. My appetite was reduced for over a week after injecting Cagri. This might mean my appetite issues are from my amylin and calcitonin receptors. YMMV.
 
I think I'm going to try to find some single doses of cagrilintide and retatrutide to see what happens! I don't want to buy a whole bunch of cagrilintide since a 5mg kit is so many doses at that low dose!
Taylor1982 said:
As always Tango, this result may only be true for me, YMMY.
Click to expand...
Thanks for the advice! I really appreciate all the help!
 
I've gone from tirzepatide to retatrutide, then cagrilintide by itself to reset, then back to tirz, and then stacked tirz+reta. A lot of switching, I know! Reta by itself messed with my blood sugar, causing low blood sugar at night and spikes during the day. I don't have diabetes or pre-diabetes, so my blood sugar is usually stable. I wanted to try tirz+reta to see if it would fix my glucose issues and still boost my metabolism. It seemed to work the first week, but not so well the second week, probably because the reta is building up in my system. I was also really nauseous week 1. I may go back to tirz+cagri. Luckily, I only ordered a couple of each. Please let us know how they work for you!
 
While I started getting nausea at the higher tirz doses, they usually recommend getting to the highest dose you can tolerate before stacking. Maybe try a slightly higher dose than 6 mg, split into two doses, or stay at 6 mg but inject every 5-6 days. If the nausea is too much, switch to reta. I stacked the two to transition when I began taking Reta at 1 mg.
 
Adding to that, getting a prescription anti-nausea medication is an option too. I've had nausea problems my whole life, so I always have Zofran handy. I'm not at high doses yet, but I'm sure I'll get nausea eventually since I always get side effects.
 
Consider the way they work. Stacking semaglutide with retatrutide can be more cost-effective. Tirzepatide is better for metabolism than semaglutide, but not as effective for appetite suppression. Retatrutide is better than tirzepatide. If you're taking retatrutide, you don't really need tirzepatide (just my opinion). Add sema to balance Reta's weak appetite suppression
 
Semaglutide did nothing for me whatsoever. I could eat whatever I wanted and feel completely normal at the highest dose. I think I felt heartburn maybe once, but it could have been me imagining things. I can't do that on tirz + reta.
 
I was on my second round of Tirz (first round I reached 15 mg) and never responded to it much. I was only on 5 mg when I got my Reta. I stacked the 5 mg of Tirz for over two months while I added 1 mg of Reta, and got to 5 mg when I stopped the Tirz. I was fine during the transition. I rarely get nauseous on Reta. It still provides the anti-inflammatory benefits that Tirz did. I usually take Tesofensine too but I'm on a short break right now.
 
My partner (RS) wasn't having much luck with Tirz, even at 5 mg, but adding 2.5 of Reta immediately improved their appetite suppression and eliminated food cravings. Now it's hard to for them to find food that they even want to eat.
 
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