Tirz stability after mixing?

G

Green_Sis

Well-known member
I've been thinking about how long tirz lasts after you mix it. Most people use regular BAC water, but some use it with extra sodium chloride. I haven't seen a lot of chat about how stable it is, or if anyone uses buffered solutions.

Mounjaro pens last a long time, so mixed tirz should be good for months. But the pens have phosphate buffer (5 mM, pH 7.0) and NaCl (140mM, 8.18 mg/mL), which help keep the peptide stable (patent application: https://patents.google.com/patent/WO2024086601A2/en).

From what I can tell, NaCl really helps with stability, and buffering might be needed for longer storage (tirz breaks down in lower pH). I'm wondering how important all this is for peptides mixed from powder, kept in the fridge, and used in a few weeks or months. Anyone have any ideas? Have you seen if it seems weaker over time?
 
Wow, I thought I'd read everything about BAC water, but I've never heard about adding NaCl.

For what it's worth, I've been mixing tirz for a while and I don't stress about shelf life.
 
Janoshik says it doesn't matter which solution you use. Both should last for months, not weeks. He did a Q&A on Peppys where he debunked a lot of common beliefs about mixing, solutions, degradation, how fragile they are, vendors, and more.
 
It's basically saline with benzyl alcohol. The idea is that it's isotonic, so it causes less damage and less pain. Lilly says that the right amount of NaCl also makes tirz more stable by balancing peptide oligomer size.

I'm on 2mg now, and if I stay at this dose, a big vial would last almost half a year. I'd hate for it to break down, especially if I could stop it. 🙂

Filtering would kill bacteria, but I'm worried about the peptide breaking down. I've read that tirz is sensitive to pH.

Oh, I'd love to read that! I haven't heard of Peppys. Since it's private, I can't... 🙁 Also, some peptides are more stable than others, so it might depend on the peptide.
 
To join Peppys, search here for “join Peppys.” There are some clues. One of the admins checks messages regularly. You'll find her!
 
I use BAC saline because:

* I can get smaller bottles so less waste and I feel safer about contamination.
* It's more comfortable. The plain BAC makes me feel it more when I inject.
* It's not much more expensive.

Just my opinion, of course.
 
Yeah, I found a peptide calculator that is pretty useful for figuring out how much water to add for accurate dosing. It's at Peptide Calculator | Free & Accurate Tool for Dosage & Reconstitution. It even accounts for blends!
 
I'm with @Stevie_1997. I mix it and inject it. Never had any issues with potency dropping. But I also don't store for longer than 2 months after mixing. Probably overkill but gives me peace of mind.
 
Thats reassuring to hear. I've been trying not to stress too much about storage since I use mine weekly anyway. Left a batch sitting out for a few months before testing once, and results came back clean. Keeping it in the fridge now and it's been stable for a few more months.
 
Took me a while to reach 7.5. I've been on Tirz for about 3 weeks after spending 1.5 years on semaglutide, and I've been stuck at the same weight since July. Wondering how long before things shift.
 
My dad pays 30 bucks a month for his Mounjaro but bailed after a few weeks with reflux. Insurance coverage is the real scary part - you never know when they'll flip the switch.
 
Been on this for about three weeks starting at the 2.5 dose. Stomach stuff is the main problem for me. Next day after injection I basically need to stay close to a bathroom. Hesitant to go up in dose next month with how intense this is.
 
Daily since taking a Tirz break until after daughter's wedding in March. If numbers climb I'll restart if needed. Month in fluctuating one twenty five to one twenty eight happy about it original goal was one fifty.
 
The 250mcg sensitivity is the case for conservative concentration - BAC-mixed tirz at standard dilution gives a 28-day refrigerated window. First-dose response is the baseline for calibrating what concentration actually works for you.
 
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