Tirz vial - How long is too long?

Lil_Cookie

Lil_Cookie

Well-known member
Hey everyone,

I'm curious about the maximum amount of time you all use a single vial of Tirzepatide after mixing it. I've seen some suggestions that it's only good for about a month due to the bac water, but other opinions seem to differ. I'm not expecting a definitive answer, just looking for some personal experiences and advice. Thanks, GLP community!
 
@Lil_Cookie You're right, there's no single right answer!

I've noticed across various peptide forums that this question seems to provoke strong opinions, many of which probably aren't based on any real research!

So, I'll throw my hat in the ring with my own subjective and potentially incorrect answer: My personal experience is that I don't detect any noticeable change when comparing freshly mixed Tirzepatide to a vial that's been refrigerated for up to two and a half months, both purchased from the same place at the same time.

My spouse and I were easily able to tell the difference with another GLP-1 that was supposedly 20% stronger. I'm assuming a degradation of 20% in potency would be noticeable.

My totally unscientific conclusion, which only applies to my wife and myself, is this:
* GLP-1 peptides kept refrigerated for up to 2 1/2 months seem to decline by less than 20% in effectiveness, probably much less.

Bring on the criticism! [quotes Lil_Cookie: ""]
 
Most guidelines say 30 days.

I've personally used a vial for 2 months or even longer. When I start researching Cagri, I plan to use it for an extended period because the dosage is so small (10 mg vial).

You'll get a lot of different opinions. Just be sure to maintain sterile procedures when handling your products. That's the key to safety.
 
That's exactly the kind of info I was hoping for! I appreciate you sharing your experience. While n=1 or 2 doesn't carry a lot of weight, it's valuable to hear from someone who's gone well beyond 30 days just to get a sense of things. Thanks for your input!
 
Yes, excellent point about keeping everything sterile when using a vial for a longer duration. When are you thinking of starting your Cagri research?
 
I'm new to this, so I want to make sure I understand correctly. If I'm taking 5mg weekly, I could order a 60mg vial and use it up over 11 weeks, which is about 2-1/2 months. Is that a reasonable thing to do?
 
It's not really ideal. For the 2.5mg dose, I'd suggest starting with a smaller total vial size if you can. But I understand it's often cheaper to use a larger vial like 60mg. It's possible the reconstituted vial could lose some strength by the time you're getting to the end of it. Be sure to keep the vial in the fridge and always use alcohol wipes and fresh needles.
 
I'm currently using a 17.2mg Tirz, dosing 1.9 mg/week. That's about 9 weeks per vial. Everyone has different comfort levels with risk, but here's my reasoning.

I have medical training and know how to use sterile techniques.
I'm the only one handling the vial, and it's only punctured once a week with a fine needle.
It's injected under the skin, not into muscle or a vein.
It's refrigerated between uses.
I have a good immune system.

That's the thing about this whole DIY peptide world: You get to decide, but you also have to deal with the results. Complete power, complete accountability.

So, to answer your question directly, it might be reasonable, but it depends on your own situation.
 
I think that's totally reasonable about storage time vs. effectiveness. I've used GLP1s that were 90 days old and they seemed just as good.

Since we're in a "single-patient/multiple-uses" situation, there's no worry about cross-contamination - which is the main concern and the reason for the FDA's 28-day rule after opening.
 
ByeByeBelly73 said:
I'm new to this, so I want to make sure I understand correctly. If I'm taking 5mg weekly, I could order a 60mg vial and use it up over 11 weeks, which is about 2-1/2 months. Is that a reasonable thing to do?
Click to expand...

From a purely medical standpoint, I agree with @walking-daily. While many do use vials longer, the risk of contamination, however small, increases over time. Smaller vials, while possibly less cost-effective, are inherently safer.
 
Lil_Cookie said:
I've noticed a big change in my appetite. It's a great reminder that we really don't need to finish everything on our plates. I'm two weeks from reducing my dosage, which is exciting and a bit nerve-wracking!
Click to expand...

That's so true! My body gets full really quickly now, but my brain is still catching up. I often order too much food without even thinking about it!
 
Regarding concerns about accurate dosing with the 1mg pen, remember you can count the clicks to get a smaller dose. For example, approx 37 clicks should give you 0.5mg.
 
Most folks starting the Lilly protocol don't jump straight to 60mg kits anyway, so I wouldn't stress. I've been at this a while and honestly don't think you'd need to toss anything as long as you store it reasonably well. Worst case, by the time you get to the bottom of the vial, you might lose a tiny bit of strength.
 
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