Tirz vs Sema for mental health?

T

Tirz_Chick614

Active member
Tirzepatide really helped me drop the extra pounds, even at the lowest strength, but my mental state took a hit. I'm thinking of trying Semaglutide instead. Anyone else made this switch and had better luck? Kinda anxious about it. Thanks!
 
I actually went from semaglutide to tirzepatide, and my mental well-being tanked. I felt zero joy, had no energy, couldn't focus, and barely lost any weight. Turns out, tirz just doesn't work for me, but sema does. I've been back on sema for about a month now and feel so much better – I can concentrate, I'm happy, I have energy again. It took me a while to figure it out, but the people around me noticed the difference even before I did.
 
I was considering tirzepatide, but my nurse mentioned that their patients seemed to do *worse* on it compared to semaglutide (which I had a terrible experience with for 9 months). I'm holding off for now.
 
I haven't tried tirzepatide, but semaglutide has been AWFUL for my mental health and focus. For the first day after my dose, I'm a total mess and barely hanging in there the rest of the week. I'm super active, can't handle being obese because of the pain and how it impacts my workouts, but I also couldn't lose weight on my own because of perimenopause. I'm halfway to my target and once I get there, I'll do whatever it takes to maintain it so I never have to touch a GLP again. Some people seem to thrive on it, but as someone who doesn't even have 'food noise,' I struggle with the fact that the weight loss is worth the "new or worsening anxiety or depression" that the Wegovy ads mention.
 
Have you considered switching to retatrutide? From what I've been reading, it seems better than both semaglutide and tirzepatide in terms of side effects.
 
Could you describe what your symptoms were? I recently switched from sema to tirz and have been experiencing a lot of anxiety, although my gut health has improved significantly. On sema, I was in a lot of discomfort even with balanced meals, but my mental state was definitely better. 😭
 
I never thought a diabetes medication could mess with your mental health... How does that even work? I figured it just makes you more tired because you're not eating as much as before.
 
I tried tirzepatide briefly last year, and my mood improved so much! It felt amazing to finally feel happy. 😭 I just started semaglutide and I'm hoping for a similar effect.
 
Mood fluctuations with these meds aren't uncommon. They influence appetite and reward pathways, so for some, that can manifest as anxiety, emotional numbness, or lack of motivation. The fact that people in this thread are reporting opposite experiences really shows how unique it is to each person. If tirzepatide negatively impacted your mental health, switching is a good idea, but mood changes are something to monitor closely rather than try to push through. If you notice anxiety or low mood returning, contact your doctor ASAP. Shedding pounds isn't worth sacrificing your mental health.
 
I agree with SoberCuriousSteve. It's so important to listen to your body and mind. I'm pushing through the anxiety for now since I'm seeing great physical results, but it's good to know when to draw the line.
 
Thanks everyone for the replies! I am def going to keep a close eye on my mood, and will check back in to let you know how the sema goes! It's good to know I'm not alone.
 
Bee_Quest said:
I struggle with the fact that the weight loss is worth the "new or worsening anxiety or depression" that the Wegovy ads mention.
Click to expand...

Totally feeling this. Like, is being skinny worth feeling like I'm constantly on the verge of a panic attack?
 
I'm still trying to adjust my self-image after losing weight. I've dropped about 20% of my body weight but still catch myself seeing the 'old me' in the mirror. It's like my brain hasn't caught up with the new reality. Is this a normal thing?
 
I am so tired of people making comments about weight now that I have lost some. I was at a family event, and someone kept telling me I could still lose more weight, even though my doctor is thrilled with my progress. It's never ending!!!
 
I think that finding a good therapist is important... I have been working on my mental health issues for a while now, and that is helping me with the mood swings that these medications can cause. It is worth looking into, especially if you have a history of depression or anxiety.
 
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