Emotional flatness, basically. One medication left everything feeling muted and distant, not depressed exactly, just never truly excited about things that used to bring genuine joy, and normally there's a naturally upbeat personality here. Switched to a different option at a smaller amount and that helped, but it's still present to some degree. Taking a week off from dosing during vacations makes the mood shift far more noticeable than any appetite change. Lost a solid amount over a couple years and it's genuinely made a real difference for inflammation and achy joints too, even at the smaller amount.