Tirzapeptide concentration over time?

Nat_92

Nat_92

Well-known member
I was wondering if anyone has looked at how serum concentrations of tirz change over time when you dose it every 4 or 5 days instead of weekly.

It should be easy to figure out using the chart below, but I'm feeling lazy and hoping someone else has already done it.
 
That's a really good link. Thanks. It's way better than using Excel. It's good for avoiding overdoses and stacking. I wonder how my rat's body would react if I microdosed 2.25mg of Triz daily? The residual level seems pretty constant, and the peak is about the same as 15mg every week. Could that help avoid a plateau? Maybe shorten the dosing period by one day each month and lowering the dose?
 
I'm not sure I understand. Are you saying that the peaks help to prevent tolerance (and reduced effectiveness)?

What data are you basing that on?

I'm guessing we're using a weekly schedule because most people are scared of needles, so the goal is to make it easy for the masses.
 
FYI, I did some research yesterday (instead of doing my pre-Christmas tasks - another rabbit hole).

It seems that peptides are usually sealed with a vacuum of around 70-80%.

I'm not sure how good my chamber vac is, but the dial reads lower than that. I'll test it later and try to stay well below that.
 
There are different perspectives. I'm taking Prograf (an anti-rejection drug), and a stable level is important to prevent rejection. This might not be as effective with GLP medications, and it could cause users to need higher dosages over time. Some argue that periods of feast and famine trick the metabolism, which might be why this dosing schedule exists, or that the peaks and valleys improve efficacy. Like intermittent fasting.

Weekly injections are life-changing for people with diabetes. A weekly GLP medication is transformative compared to managing life with insulin shots, a CGM, or finger sticks.
 
I've plotted the differences between 7, 5, and 3.5 days.

Right now, I think 3.5 days is best, twice a week to coincide with my estrogen patch change.

It maintains high enough serum levels for all the benefits, but without the extreme peaks that cause bad side effects.
 
I didn't know about these plotter things, but I've been doing two shots a week, just like my estrogen patch, and I'm almost there. I had crazy food cravings in the beginning, which wasn't normal for me, and I didn't like it. I came across a group discussing 2x a week, so I tried it!
 
I wonder if both methods (4 days or 7 days) could be right for different reasons. Maybe 7 days is better for quick weight loss, while the more consistent GLP-1 supply from the 4-day method could be good for other therapeutic benefits.

Thoughts?
 
There is a reason. However, I think the reason is that they wanted a once-weekly dose. It's easier to get people to take medication once a week.
 
I disagree that the pharmaceutical companies had to make a drug easier for diabetics. Diabetics already deal with finger sticks, CGMs, insulin injections, and daily or as-needed meds. If the FDA based approval on how forgetful Americans are, no drugs would be approved in the US.
 
I don't know many pills, even with long half-lives, that are dosed only once a week. Weekly dosing is usually for more inconvenient routes. Not having to take meds daily is an advantage for many diabetics.
 
I use this formula in Excel:

=today_doseage +previous_dosage *EXP(-LN(2)/halflife_in_days*(nextjab-today))

It looks like the above in columns.
It also calculates the elimination:
 
I've been seeing chatter about people staying on a dose until they plateau...like Lean_Set. Is that what most people are doing? Like staying on 0.5mg for a month or two?
 
You must log in or register to reply here.
Back
Top