Tirzepatide: A New Weight Loss Option?

Hong Kong Yanpep International
Ran Mounjaro for a six-month stretch and dropped 30 pounds. Stopped and gained all 30 right back. Tried ozempic for six months after that and actually gained around five pounds. Now back on tirzepatide and down 27 pounds in five months. Guessing semaglutide just doesn't work for my body.
 
Dealt with the exact same thing until I made the jump off semaglutide and onto tirzepatide not long ago. Way fewer side effects, no more that bloated feeling, and the weight's coming off again.
 
Tirzepatide's marketed specifically to help people lose weight, with standout perks like curbed appetite, quieter mental chatter around eating, and cravings that ease up.

Genuinely curious what's holding you back from trying it?
 
Side effects genuinely run worse than Tirzepatide's. Even at just 4mg, 15% of people ended up vomiting!

No argument that it's more effective though. Testing reta myself because results matter most to me, but can't shake the feeling Tirz probably suits most people better, especially those looking to drop a smaller amount compared to someone at a much higher starting weight chasing maximum loss.

Adverse event data, diabetes population:

Edit, adverse event data, obesity population:
 
The dual-action medication feels like a genuine breakthrough to me, not just for weight loss but for a whole range of other conditions too. So personally I agree it's a real game changer. That said, if this comes from the study I'm thinking of, worth flagging that the findings apply specifically to men with type 2 diabetes, not the general male population. Would love to read the actual paper but can't get past the paywall from my work account. Also a bit skeptical of any medical study leaning entirely on massive datasets to draw associations. Doesn't look like this was a randomized controlled trial either, which in my view carries more weight than a large retrospective analysis pulled from database records.
 
Generally, ramping up the dose on this drug class brings a modest boost in weight loss paired with a much bigger jump in side effects. The only compound actually tested this way is the first one, in trials running 7.2mg and 16mg, and results showed exactly that pattern. So yes, diminishing returns plus extra discomfort, but nothing alarming showed up as an entirely new adverse effect at those higher amounts
There's a higher-dose trial underway for the second compound too, but details, even the exact amounts used, haven't been released yet.

Barely seen anyone mention running the fifth compound at elevated amounts on here, so that's clearly rare.

Came across a paper attempting to project weight loss outcomes at various elevated doses across this drug class, and had an AI model estimate results for 20mg of the fifth compound using that paper's formulas, landing somewhere in the mid-30% range. Sharing that here.

What hasn't been researched yet, and really should be, is whether pushing doses higher helps people who lose below-average amounts at standard maximum doses, assuming side effects weren't the limiting factor.

Right now there's plenty of anecdotal chatter about running the second compound up to 25mg weekly, but combining a small amount of the fourth compound with 12mg of the fifth compound probably makes more sense if you're chasing over 30% total body weight loss. My take is if yo
 
In SURMOUNT-1 the placebo arm averaged 3.1% weight loss across 72 weeks, while tirzepatide participants dropped on average between 20.9% and 22.5%.
 
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