cracker_ozalumna
Member
Speaking generally here, not as advice tailored to you - in the SURMOUNT-4 trial, published in JAMA in 2024, people who lost an average of 20.9% of their weight on tirzepatide over roughly nine months were moved to placebo and ended up regaining 14% of it over the following year, meanwhile the group that kept taking it lost another 5.5% on top. This kind of regain pattern is well documented, which is why planning the stop with your prescriber matters, maybe with a gradual step-down and a checkpoint to reassess if things reverse. Hunger returning afterward is also worth flagging, since there are ways to manage that too. Anything specific to your own history or whether restarting makes sense needs a direct conversation with whoever's prescribing for you.