The tolerability variation is real - different receptor profiles mean some patients who don't do well on sema tolerate tirz or reta better. More pipeline options drives prices through competition. The emotional eating and behavioral piece is what the research is starting to catch up to.
Reta and Tirz across 10 months down 100 lbs, then 6 months off and holding - the cravings returning 'not like before' is the real indicator that the habits held. That's the test the active phase was building toward.
Tummy being last is the most common complaint here. Visceral fat stores last and leaves last. Protein and resistance work shift the composition over time but there's no shortcut to the order.
Started at 278 lbs, now at 231 lbs, aiming for 198. I'm turning 55 next week! Been on 2mg for about 2 months. I haven't been exercising, but I know I need to start soon!
You should probably lower your dose, that's what I've heard. It's OK to feel hungry if it's not overwhelming. If you're forgetting to eat or losing weight when you don't want to, try taking less medicine and see how it goes.
It's interesting that orforglipron isn't a peptide, but rather a small molecule processed by the liver. This means a higher risk of drug interactions, especially with meds that also use liver detoxification pathways. Another similar drug never progressed past phase 2 trials due to concerns about...