Coming off MJ...any success stories?

Hong Kong Yanpep International
Disgusting pricing makes them impossible for regular folks. Want section for maintenance stories but nowhere near that phase yet.
 
i'm one of those reddit people who got scared — that's why i'm here reading every day. senior on fixed income so the brand-name prices scare me. i have compounded stocked and comfortable with that.
 
Talk to your doctor first. 2.5 → 5 → 7.5 and you lost 3% but think it's slow? How did you even decide this was for you? What are you actually expecting? I'm asking seriously — you need that convo before starting any of this.
 
happened to me too. my theory is these drugs just stop working as our receptors become non-responsive over time. started back in march 2022 and by november 2024 i had zero appetite suppression left. cranked tirzepatide to 15mg for a year, gave up in march, and i'm almost two months out. hoping a break resets everything.
 
was cranking up the dose, thought i could go higher, but around 15-17mg the weight loss kinda plateaued and i felt stuck. what dose are you at now for maintenance?
 
3 weeks at 2.5mg and the initial experience settling in is right where you would expect to be. 198 as a starting point is a number a lot of people here started at too. How much were you hoping to lose and what does the appetite feel like so far?
 
The 8-week calorie increment plan alongside titrating the dose down over the same period is the right approach for avoiding the rebound effect. Doing both simultaneously rather than just stopping the medication gives the body time to adjust to each new level. How are you tracking the maintenance calories as you build back up?
 
Finding 5mg as the effective ceiling and staying there is one of the cleaner titration stories - starting low, giving each dose real time, and only going up when the loss actually stalled. A lot of unnecessary nausea comes from jumping before the current dose has been given a proper run.
 
Ran mounjaro for a stretch back before it got popular, back when the manufacturer was handing out $25 coupons to everyone. Regained everything once I stopped. Definitely feels like a lifelong medication situation, but I do worry about how well it keeps working over the long haul.
 
Started off the same way honestly, but a full year in now and my body just doesn't react as strongly to the dose anymore. Held at 2.5, 5, and 7.5 for four months apiece, and now with a year on this medication under my belt I'm bumping up to 10mg.
 
Mind if I ask what kind of ED you developed? Mounjaro's basically a lifelong medication for people dealing with obesity, and as a 45-year-old guy I honestly can't judge what your starting weight meant in that context, but any doctor pulling you off MJ over an ED just doesn't fully understand the situation. Sounds like counseling is what's needed here, not losing access to a medication that's genuinely helping.
 
You're on a really tough road, genuinely tough. Nice work so far! Six months brought a serious amount off, seriously significant. Stalls happen, what percentage of your starting weight have you shed so far? Mounjaro's clinical data showed the average ceiling sits around minus 25% of original body weight. Could be you've hit that ceiling and your body's fully adapted to the drug.

My two cents after reading your post, might be worth chatting with a dietitian about what's happening, and lining up some emotional support too, this stuff is exhausting and you're clearly carrying a lot of expectation and stress about it. After that, consider raising the dose if that's an option and watch for any shift.

Wishing you the best either way!
 
Feels like more detail would help here:

How long has this drug class been part of your routine?
How much have you already lost, and what's your current weight and height?
How long specifically have you been sitting at the moderate dose?
 
A solid stretch on mounjaro now, lost a substantial amount overall. Spent much of the back half stalled out. Movement's picked back up at the higher dose, but since there's not much room left to climb, ready to accept slower monthly losses again going forward. Tried a couple other GLP-1 options before this one, neither matched the results despite costing less. Daily injections with one of them were rough for me personally. Another option sent me into a real emotional flatness spiral, wouldn't recommend it. Stick with this drug class, move the dose up whenever it makes sense, wishing you the best.
 
Would you share your age, and do you have T2D? Same boat here. Next week I go to 7.5mg, after 2.5mg for six weeks and then 5mg for six more, 12 weeks total. Saw a little movement on 5mg, but food noise and glucose aren't where I want them. My weight bounces around, 4 pounds down one week and back up the next, or 2. About 4 pounds lost overall. My doctor agreed to raise it, with a return to 5mg if side effects turn bad, though honestly I have none. It's discouraging to hear everyone's losses when you count calories and water, exercise, and barely anything moves, with my glucose sometimes high. A bigger dose is probably what I need. Happy for your success!
 
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