This checks out, been over a year now, but between the first four 2.5 doses and two weeks into 5, the weight dropped fast, close to 30 lbs almost immediately, after years battling insulin resistance, diabetes, and fatty liver through diet alone, so that early momentum had me thrilled. Had to pause for two months over insurance issues, then finally restarted, and I have lost more, but it's been a grind these past several months chasing this remaining 20 lbs. Lately I've been nervous I'll need to switch medications, I know there's no quick fix here and switching would probably work out better long run, I was just hoping to see even a pound or two move weekly, but my body's probably just taking its own time to adjust. Did drop close to five clothing sizes though, still 45 to 50 lbs from the finish line, but it'll happen.