Honestly had some genuinely rough stretches on this medication at every dose, sometimes kicking in roughly six weeks after a dose increase, other times not until well past a month with no obvious cause.
Still worth it in the end.
Or the alternative is dealing with feeling unwell, uncomfortable, and unhappy through what's statistically likely to be a shorter life than staying at a healthy weight would give you.
Unless there's another route to losing the weight, you kind of just have to push through it.