GLP-1s losing steam after a while?

I go up in small increments too, trying to avoid heavy side effects. My appetite is basically gone, but I raise the dose hoping to restart the loss.

Glad to hear it isn't just me. Nearly through my first month at 5 and it feels weaker than 2.5 did. Hunger chatter returned and glucose is inching up although my diet hasn't changed. Frustrating, since 2.5 helped so much.

Could you ask your doctor about switching GLP1s, maybe to Mounjaro? My doctor told me it works better for food noise.

My guess is plenty of people here carry some condition that never got flagged, which would explain why reactions swing so wildly between users. Some folks truly feel nothing from these meds, straight up non-responders. Others clearly deal with insulin resistance, and for that group it tends to work really well. Personally, hunger just disappears completely for me, to the point I can lose my appetite entirely. Moving the dose up to 5mg left me struggling to finish even two bites. Definitely a strong responder here - dropped around 10 kilos while sitting at just 2.5mg and held there for six months straight. Only increased the dose since my IBS started flaring again as my body adjusted to it.