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The tolerability variation is real - different receptor profiles mean some patients who don't do well on sema tolerate tirz or reta better. More pipeline options drives prices through competition. The emotional eating and behavioral piece is what the research is starting to catch up to.

Reta and Tirz across 10 months down 100 lbs, then 6 months off and holding - the cravings returning 'not like before' is the real indicator that the habits held. That's the test the active phase was building toward.

Tummy being last is the most common complaint here. Visceral fat stores last and leaves last. Protein and resistance work shift the composition over time but there's no shortcut to the order.

I'm trying to decide what kind of exercise to start with. My knees aren't the greatest, so I need something low impact. Any suggestions?

You look great too! Beautiful!

Started at 278 lbs, now at 231 lbs, aiming for 198. I'm turning 55 next week! Been on 2mg for about 2 months. I haven't been exercising, but I know I need to start soon!

You look amazing! Great job!

Woo hoo!

I'm 68 and on Wegovy. Zero issues so far.

Yeah, that's my fear! I don't want to lose my hair or anything like that. I'm already losing weight pretty fast, so I'm going to talk to my doctor.

You should probably lower your dose, that's what I've heard. It's OK to feel hungry if it's not overwhelming. If you're forgetting to eat or losing weight when you don't want to, try taking less medicine and see how it goes.

Bloods are always a good idea! ❤️

What's the recommended starting dose?

It's interesting that orforglipron isn't a peptide, but rather a small molecule processed by the liver. This means a higher risk of drug interactions, especially with meds that also use liver detoxification pathways. Another similar drug never progressed past phase 2 trials due to concerns about...

Which vendor is that? I can't find them.

Where did you get the orforglipron? Are there any reasonably priced sources besides Uther? A DM would be great if you're comfortable sharing.

Is this something to do with that old movie?

I actually drink more coffee since starting GLP1s. It tastes better, and I like the way it makes me feel. I quit nicotine cold turkey right after starting Ozempic. Quitting was rough, but I think Sema helped.

I feel you, NSV_Hunter. Before starting tirz, I limited my fast food trips to once a week. Now it's more like once a month, if that. The last few times I've indulged (two burgers, medium fries, medium soda) I enjoyed it at first, but then felt awful for hours afterwards. It's trash food, but can...

It seems pretty clear that GLP-1s effects on cravings are all over the map. It probably varies wildly from person to person. I gave up alcohol almost immediately after starting tirz, but my smoking and coffee habits haven't changed a bit. I know others who quit smoking but still enjoy a drink...