Anhedonia on Tirz - anyone else?

Hong Kong Yanpep International
ShrinkAF

ShrinkAF

Well-known member
So, I'm taking Tirz, and it's really helping with the cravings and quieting down the constant thoughts about food. But I've noticed I don't really enjoy doing my hobbies lately. It's like my brain is just 'meh' about everything. Is anyone else dealing with a lack of pleasure on this stuff? Any tips to get my mojo back?
 
Hang in there. Seriously, it took a few months, but my brain eventually adjusted. It was like it was throwing a tantrum at first, demanding the dopamine hit from food, but eventually it realized that wasn't happening anymore and started looking for other sources of enjoyment. Now I'm genuinely happy doing other stuff again. It just takes time for your brain to rewire itself.
 
It could also be tied to the calorie deficit and weight reduction itself, not just the medication. If you've lost a significant amount of weight over a longer period, that might be it. Have you tried just forcing yourself to do things you used to enjoy? Sometimes just getting started can kickstart the positive feelings. If you're early on and haven't lost much, then it's probably the Tirz. Maybe Reta would be better? Also, don't psych yourself out too much. Placebo is strong, and if you are expecting it to make you feel bad, it might.
 
Ghost-of-Donuts-Past said:
If you're early on and haven't lost much, then it's probably the Tirz. Maybe Reta would be better?
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I'm down maybe 8-10 pounds the last 6 weeks, so yeah pretty early. I'll ask my doc about Reta, thanks!
 
Guys, I've gone down almost 70 pounds over the course of my treatment. I feel so much better about my body. I fit comfortably into regular sizes. I used to dread clothes shopping. Now I actually enjoy it!
 
I'm hoping I get the mental benefits some of you are talking about. Right now it's just blah. I know some people have amazing experiences. I saw someone on the reddits say, "My mental health has improved significantly. My overall mood is unlike any time I can remember." I NEED that!
 
shedding 20kg in 4 months is solid work. compare and despair kills joy. those before-afters on peptide vendor posts are doctored anyway.
 
The anhedonia getting worse with higher doses is a real pattern and worth taking seriously - GLP-1s affect dopamine signaling pretty broadly, not just food reward. If it gets worse with dose increases that's a signal to go back down rather than push through. Worth talking to whoever prescribes it, this isn't just sadness.
 
The anhedonia plus constant sleepiness combo is one of the harder side effect profiles to push through because it affects quality of life in ways that don't go away on their own the way nausea sometimes does. If it's been more than 6-8 weeks at the current dose, it's worth raising with whoever prescribes it - sometimes a dose reduction resolves it.
 
The reward circuit dampening affecting areas beyond food is the common description of what gets called anhedonia on GLP-1 - the mechanism that quiets compulsive food drive appears to extend to other high-reward activities too. For most people it is temporary and dose-dependent, but worth tracking whether it is affecting quality of life beyond just appetite.
 
Anhedonia persisting at 5mg after titrating down from higher doses is worth tracking on a timeline - the dopaminergic effects tend to take longer to recover than the appetite changes. How long has it been since you started coming down and is the anhedonia stable or still improving? That trajectory matters for knowing whether it resolves or requires further dose adjustment.
 
Wow, how did that whole experience play out for you? It really messes with habits and anything that normally triggers a dopamine hit. Wasn't prepared for that side of it either.
 
Not much of an energy drink person myself, but the psych meds struggle definitely resonates. Went through several different SSRIs over the years, definitely packed on weight and lost energy from those. Only on a low dose of vyvanse now for focus, barely enough to actually get moving, just keeps things alert enough to function through the day.
 
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