Anyone tried AOD-9604?

Hong Kong Yanpep International
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Titration_Station

Active member
I'm interested in hearing about experiences with AOD-9604, especially when used alongside a GLP-1 med. I've seen conflicting reports. Some say it's useless, essentially just a waste of money. Others claim it aids in fat loss. Given it's marketed as an anti-obesity compound, I'm curious if it actually delivers and how. Does it increase metabolism? I've read that it prevents fat storage.
 
I went through a complete kit plus two extra vials of AOD. It didn't do anything beneficial and just cost me money. I wish there was a way to resell unused stuff when people realize it's not for them.
 
My partner and I experimented with it for several months. In our experience, it performed similarly to its performance in human trials that I looked up, meaning it was totally ineffective. A total waste of funds.
 
The effects are minimal at best, definitely not worth the expense. It's generally considered to only be effective when used in combination with a GLP-1 agonist. There are far better things to add to a GLP-1 than AOD to enhance results. However, I'm not judging anyone who finds it beneficial. Everyone responds differently.
 
It literally does nothing. The receptor it targets in rodent studies doesn't function the same way in humans. The lead scientist from five out of six clinical trials for the company that developed it has said it's ineffective.

It was abandoned after a ton of money was invested for a reason.
 
Speaking of things that maybe don't work as well... anyone have experience with BPC-157 impacting libido? I've seen some anecdotal reports of decreased drive.
 
IF-warrior, I've seen that too. Some people online mention BPC-157 potentially affecting dopamine and causing mood issues. It's not a super well-researched area in humans, though.
 
Anyone tried Ipamorelin for weight loss? I'm trying to drop another 20 pounds or so. My diet is pretty clean, lots of lean protein, fruits, and vegetables, plus HIIT workouts.
 
Witty-IMO said:
Anyone tried Ipamorelin for weight loss? I'm trying to drop another 20 pounds or so. My diet is pretty clean, lots of lean protein, fruits, and vegetables, plus HIIT workouts.
Click to expand...
It sounds like you're already doing all the right things! Ipamorelin might give you a *little* boost, but don't expect miracles.
 
Any luck with peptides for lupus stuff like tiredness, rashes, joint pain? My rheum has me on hydroxychloroquine but it triggers histamine nightmares since it tanks immune function. Tried ss31 and mots c, got knocked down hard. Also grabbing thymosin alpha 1 plus bpc157 for joints. Thoughts?
 
Found the FDA risk list for compounded bulk substances. Pairs with that immunology chart someone shared — worth a review if you're using compounded versions.
 
compounded versions aren't brand-name approved, but the drugs themselves are well studied and proven safe. not the same as untested peptides. real difference.
 
Is the whole kit from one batch so testing one vial covers the rest? And group tests just split the cost? Been on compounded tirz but FDA crackdowns scare me. Seen the endotoxin and sterility drama and I'm nervous about the switch.
 
The 'not in the target market' pushback on AOD-9604 opinion is a fair point - the response to most of these compounds is highly dependent on whether you actually have excess fat to mobilize. Someone at lean body composition is going to report very different outcomes than someone using it as part of a GLP-1 stack for meaningful weight loss.
 
Lipedema is where it works, weight loss isn't. I mentioned recently that certain women, after big losses on GLPs, kept lipedema in their legs, and AOD fixed that. I'm skinny fat wanting to drop just 12 lbs, mostly around the belly, so I tested it. Weight loss? Zero and my belly fat's skin and volume didn't improve.
 
I'm trying AOD because it's less likely to affect insulin resistance. I'm on tirzepatide after earlier T2D, and AOD looks like a good first step into a growth hormone secretagogue trial, before things like CJC, IPA, Serm and Tesa. I can't say yet if it's effective, but I think it's improved my sleep quality a lot.
 
Lots of people online say Reta with AOD alone gave them a stronger effect than Reta by itself. The AOD trials get waved away by many, yet they need context: when and how they were done. They tested it as a standalone peptide on people who changed nothing else in their lives. The goal back then was a weight loss product for people making zero lifestyle changes, hence the mixed results. Its mechanism is sound but needs a calorie deficit to work fully, which is exactly why GLP-1s complement it, and why the pairing keeps coming up in conversations like this one. Thats how it was explained to me anyway.
 
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