Multi-day fasting genuinely helped while running reta. Dropped 60 lbs doing extended daily fasting windows over a good stretch of time. Threw in a handful of 72-hour stretches too, just to test my limits, ha. Unfortunately let it slide eventually, regained about half of it back, and restarting just never clicked the same way again. Must've thrown off my metabolism somehow. Fasting's honestly great though, and I'll never fully abandon it. Fasting also taught me to lean hard on protein plus fiber to hang onto muscle, and without that lesson my learning curve on reta would've been way steeper. This drug class is honestly a lot more forgiving than the discipline fasting demands.