Constant Tiredness on GLP-1's?

Hong Kong Yanpep International
I've heard similar things about Sermorelin affecting sleep. Some people get carpal tunnel-like pain that wakes them up. Others just can't stay asleep. It's a bit of a gamble, it seems.
 
If you're really obese and cut calories super hard, that much loss is normal. But you're not actually learning how to be healthy or fueling your body right. Learn to eat like a regular healthy person—good protein, real carbs not junk, good fats. Work with a dietitian if you don't know how. Meds are serious and you'll need to maintain eventually.
 
hydrate and aim for 30–50g fiber daily. my breakfast is either a carb-balance burrito (28g fiber) or high-fiber cereal with an oikos shake. add legumes or beans to lunch and dinner. lots of fluids overall.
 
The 'up at 4am checking peptide forums' energy is at least something, even if the tiredness is real. If the fatigue is more than the first couple weeks of adjustment, it's worth checking whether you're eating enough - the combination of caloric restriction and the medication's effects can create a deficit that hits harder than expected.
 
the every 2-3 hour eating strategy is the right instinct if you suspect blood sugar dips are behind the fatigue - the sustained low-level input keeps glucose from dropping into the range where energy crashes. a CGM for a week would settle the question of whether it's actually blood sugar or something else, but the dietary approach you've started is a reasonable way to test the hypothesis first
 
Yikes, that sounds rough. Any chance you've got sleep apnea or something along those lines? Or is this just the medication doing it?
 
Apparently fatigue shows up in roughly 5% of people taking this drug class. Possible contributors include not eating enough, dehydration, poor sleep, that kind of thing. Research suggests it typically improves though. The official prescribing information is publicly available from the FDA if you want to dig into it yourself.
 
Lots of good input here already. Worth mentioning I started this medication class back in October, right as days started getting shorter heading into winter. By February, roughly where you're at now, I could barely drag myself out of bed. Just completely drained, every single day. That exhaustion improved gradually over the following months.

Try upping your intake of the sunshine vitamin and a vitamin C supplement, and staying properly hydrated. And give it time. It genuinely does get better, promise!
 
Glad to hear someone else deals with the extreme exhaustion too. Mine shows up more as a total lack of drive. Working from home, and just getting through the day feels brutal. Ended up needing a lunchtime nap just to function.

Being on a GLP1 is honestly nothing close to easy. Feels like managing the side effects takes constant effort, and I've only dropped 21 pounds across three and a half months. Expected more given I started at 257. I'm a 55-year-old woman, still menstruating regularly. Thought this whole process would move faster, but progress is progress!
 
My tiredness has been around 2 years already, and I have only used peps for 14 weeks. A few years ago my testosterone and bloodwork looked fine. Still, with GLP use it makes sense that some get less energy from eating less. Yep, I now take a lot of vitamins since starting reta.
 
Fair warning: the calorie restriction that comes with a GLP1 probably brings the same fatigue. I understand the schedule problem, since finding time and drive for exercise is hard for me too. Chances are I'd regain if I quit. Luckily (?), a T2DM diagnosis a few years back means I'll still qualify even on Medicare next year. Protein is a struggle for me. Many exercises are hard for me too, and it isn't only laziness, the weight loss worsened my orthostatic hypotension a lot. I began swimming a couple of times weekly, but three surgeries in the past year and a half each pulled me out of the pool for anywhere from six weeks up to a quarter of a year. Someday....
 
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