Not sure honestly, but there's apparently a genetic variant that caps weight loss around a small single-digit percentage for some people... also had thyroid panels come back showing a low active hormone marker, borderline low on the free version too, which definitely ties into metabolism.
Everyone keeps saying the starting amount here was extreme. What's actually documented is a smaller opener followed by roughly doubling on the next titration step... versus the informal community approach where everyone starts this compound at a tiny fraction of that and stays there for half a year, complete with an entire thread's worth of it's not working posts?