Extreme Fatigue on Reta

[grumpylateadopter3]

Anyone else dealing with extreme fatigue on reta? Been on it about four months now, at the higher end of dosing for around six weeks. Tired constantly. Getting a full eight hours overnight and still need a three hour nap on weekends. Practically falling asleep at my desk. Can't stand it anymore. Are there any compounds that could help combat this kind of fatigue?

 

[tipsyramen]

Felt the most from ss-31 last summer honestly, really cut through brain fog. Nad+ gave clean energy, actually cut coffee entirely while running it, mainly trying to counter fatigue from reta. This latest round I just went all in, highest concentration vials, pushed doses and duration to finish everything the same week. Nothing fancy, just going hard.

 

[tired_dreamer77]

New week here. Bumping tesa up to 1.25mg daily mornings and increasing reta to 4mg twice weekly. Tesa seems to give a small mental lift that cuts through some of the foggy fatigue from reta. No other side effects worth mentioning.

 

[restart_daily]

Morning. Stayed on my starting dose for a long stretch, actually still holding there for maintenance. Worked perfectly for me, never needed to bump it up. My doctor did suggest raising it for a month once, and that led to extreme fatigue, so I brought it back down. Genuinely believe in sticking with the lowest dose that actually works, same as with any medication. Key word being 'works' though. If the current amount isn't cutting it, then yes, raise it. There's a very small slice of people this medication just doesn't work for, that possibility exists, but it's genuinely uncommon. Before giving up entirely, try bumping to the next level first.

 

[snug-fig35]

Never heard of reta making anyone tired, so news to me. Thanks for the heads up. I know older people with low GH tend to get fatigue, but a morning shot of 1-2 iu of 191aa clears it up.

 

[ryehummer]

No fatigue on Reta for me, or for my wife. We both began at 2mg and both sit at 5mg now. Ours is a twice weekly schedule, not sure if that matters. We have also cycled a few mitochondrial peptides, and run NAD+ on and off through the week.

 

[homey_runner]

I lived on caffeine tablets and energy drinks for decades, so I get the pull. On GLP-1s they backfired for me. They cover the fatigue for a bit without fixing it, and the crash on reta feels far worse. I seemed to process caffeine differently, and my sleep suffered even more than before. Priority for me is eating, drinking, electrolytes and rest. Energy drinks are rare for me now. These days I use MOTS-c and 5A1 for fatigue.

 

[salty_walker]

Five mg of reta, then .5 three days later, is how I run it, and it adds a bit of tiredness, though it's manageable. Cagri goes in at bedtime so the first wave of tiredness passes while I sleep, and MOTS-C follows the next morning, which helps as well.

 

[snug_snacker91]

Since starting reta I've moved to polyphasic sleep and gotten used to genuinely naps. My work is largely asynchronous, I just schedule video calls a bit differently, and it doesn't affect me much. I realized a lot of my fatigue wasn't sleep-related. I have type two diabetes, and with my blood sugar dropping so much I paused metformin. Turned out metformin caused my morning fatigue (lactic genuinely acid). I've done several genuinely cycles of genuinely SS-31, MOTS-C & 5-amino-1-MQ, & swapped B3 (niacin) for NR, which suits me better. They cut fatigue a lot but don't change the need for sleep. I also raised my coffee, and as a fast caffeine metabolizer it doesn't hurt my sleep, it just refreshes me after naps. No tea desire since reta, so I can't say, though worth a try.