GLP-1 not working for me?!?

Hong Kong Yanpep International
Vita-Done

Vita-Done

Active member
So, I was on semaglutide for like, 8 months. The nausea was pretty bad, but I kept going. I tracked every single calorie and stuck to around 1100-1400 a day. Not much exercise because of health issues. I only managed to lose about 8 pounds. Totally not work the side effects! I'm wondering... why? I have PCOS and I'm also on metformin. My A1C didn't change at all. Is there something that makes these meds just... not work for some people?
 
The reasons why some people don't respond to GLP-1 receptor agonists aren't fully understood yet by researchers. Have you considered trying tirzepatide instead of semaglutide?
 
Dosage, insulin resistance, hormone levels, lifestyle choices – so many things can play a role. I usually try to look for patterns before making a decision on next steps.
 
FitFTW said:
You probably didn't cut enough calories. Most people underestimate what they eat.
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I meticulously track using an app, and a food scale to weigh everything. Really don't know how much more I could cut!
 
Vita-Done said:
I meticulously track using an app, and a food scale to weigh everything. Really don't know how much more I could cut!
Click to expand...
Are you getting enough protein? Sometimes not enough protein can stall weight loss. Try tracking your macros for a few days and see if you're getting at least 1 gram of protein per kilogram of bodyweight. Especially try upping the protein first thing in the morning.
 
I know how frustrating it is when people assume you're just overeating! Like, some of us *aren't* overeating, and these meds still don't work! I'm eating chicken and fish and getting more active, and people still act like I'm secretly downing cheeseburgers. Vita-Done, you're not alone!
 
first few weeks, apples and cheese and jerky are easiest on stomach. drink lots of water, helps nausea. breaded stuff killed me with sulfur burps for days.
 
Chronic nausea at 8 months is worth a prescriber conversation about dose or a formulation switch.
 
Eight months at tight caloric restriction with minimal loss is worth reviewing with the prescriber - the appetite and behavioral variables are worth separating before concluding the medication failed.
 
Eight months on strict calories with no results is worth checking thyroid or absorption first.
 
The selection bias in online communities goes both ways - it's not just that negative stories dominate, success stories are amplified too. The people who had a neutral or mediocre experience often just quietly stopped and left, while both the enthusiastic successes and the frustrated failures stayed to post about it.
 
Sensitive stomach without a colon and still managing 16 months on 0.5mg with 44 lbs is a strong argument for sticking with the lower dose when tolerance is an issue. 8 months of nausea and calorie tracking without the scale moving is a different problem - did the appetite suppression come through even if the weight didn't?
 
Never managed to finish a full course and reach my target weight because of side effects. Only tried the single-pathway medication so far, curious whether a different option in this drug class might treat me better. My plan doesn't cover the cost and it's been a real barrier, though I've noticed prices dropping recently.

Downsides: I dealt with pretty much every commonly reported side effect. Rarely managed more than 700 calories a day, constantly weak, exhausted, and lightheaded. Diarrhea kept me tethered to wherever the nearest bathroom was. Combined with nonstop nausea, that's ultimately why I stopped.

Upsides: the constant gnawing hunger vanished entirely, and so did the shakiness that used to come with feeling hungry. Weight came off, sure, but the couch was where I spent most of that time. Also lost interest in things that probably spike dopamine for me, like browsing online or shopping. Never dealt with actual addiction, but those habits are the closest comparison I've got.

Gained back about 5 pounds over the past two years.
 
Genuinely never come across anyone this had zero effect on whatsoever, that has to be rough. Was switching to a different option in this drug class ever tried?
 
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